Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

The biogenesis, folding, and structure of α-helical membrane proteins (MPs) are important to
understand because they underlie virtually all physiological processes in cells including key …

It is unclear how binding of antidepressant drugs to their targets gives rise to the clinical
antidepressant effect. We discovered that the transmembrane domain of tyrosine kinase …

Fibroblast growth factors (fgfs) are widely believed to activate their receptors by mediating
receptor dimerization. Here we show, however, that the FGF receptors form dimers in the …

Protein folding homeostasis in the lumen of the endoplasmic reticulum is defended by signal
transduction pathways that are activated by an imbalance between unfolded proteins and …

Excessive exposure to benzene has been known for more than a century to damage the
bone marrow resulting in decreases in the numbers of circulating blood cells, and ultimately …

Membrane proteins (MPs) play essential roles in numerous cellular processes. Because
around 70% of the currently marketed drugs target MPs, a detailed understanding of their …

Transmembrane (TM) helices of integral membrane proteins can facilitate strong and
specific noncovalent protein–protein interactions. Mutagenesis and structural analyses have …

To initiate biofilm formation, it is critical for bacteria to sense a surface and respond precisely
to activate downstream components of the biofilm program. Type 4 pili (T4P) and increasing …

The MARTINI coarse-grained model is used to gain insight into the association of WALP23
helices in three different lipid membranes: DMPC, DPPC and DOPC. Potentials of mean …