The past several years have witnessed an increased presence of control theoretic concepts
in synthetic biology. This review presents an organized summary of how these control …

Recent progress in DNA manipulation and gene circuit engineering has greatly improved
our ability to programme and probe mammalian cell behaviour. These advances have led to …

Engineered genetic circuits for mammalian cells often require extensive fine-tuning to
perform as intended. We present a robust, general, scalable system, called'Boolean logic …

Every plant is closely associated with a variety of living organisms. Therefore, deciphering
how plants interact with mutualistic and parasitic organisms is essential for a comprehensive …

A fundamental challenge in synthetic biology is to create molecular circuits that can program
complex cellular functions. Because proteins can bind, cleave, and chemically modify one …

The vision of assembling molecules in a manner similar to a factory, where parts pass from
workstation to workstation, is highly appealing. A key requirement to achieve such control …

Small molecules that specifically activate an intracellular protein of interest are highly
desirable. A generally applicable strategy, however, remains elusive. Herein we describe a …

Employing small molecules or chemical reagents to modulate the function of an intracellular
protein, particularly in a gain-of-function fashion, remains a challenge. In contrast to inhibitor …

The innate immune system has evolved under selective pressure since the radiation of
multicellular life approximately 600 million years ago. Because of this long history, innate …

Assay devices designed for these applications offer improvements to existing methods or
provide fundamentally new strategies. Both mature methods and novel techniques have …