Primary cilia, antenna-like sensory organelles protruding from the surface of most vertebrate
cell types, are essential for regulating signalling pathways during development and adult …

Primary cilia are solitary, immotile sensory organelles present on most cells in the body that
participate broadly in human health, physiology and disease. Cilia generate a unique …

Cells interpret a variety of signals through G-protein-coupled receptors (GPCRs) and
stimulate the generation of second messengers such as cyclic adenosine monophosphate …

The borders between cell and developmental biology, which have always been permeable,
have largely dissolved. One manifestation is the blossoming of cilia biology, with cell and …

Satellite cells are required for the growth, maintenance, and regeneration of skeletal muscle.
Quiescent satellite cells possess a primary cilium, a structure that regulates the processing …

The past decade has seen significant advances in our understanding of Hedgehog (HH)
signaling pathway in various biological events. HH signaling pathway exerts its biological …

Phosphoinositides (PIs) are phospholipids derived from phosphatidylinositol. PIs are
regulated via reversible phosphorylation, which is directed by the opposing actions of PI …

Optogenetics combines light and genetics to enable precise control of living cells, tissues,
and organisms with tailored functions. Optogenetics has the advantages of …

Autosomal dominant polycystic kidney disease (ADPKD) is a life-threatening monogenic
disease caused by mutations in PKD1 and PKD2 that encode polycystin 1 (PC1) and …

Many neurons in the central nervous system produce a single primary cilium that serves as a
specialized signaling organelle. Several neuromodulatory G-protein-coupled receptors …