Ceramidases catalyze hydrolysis of ceramides to generate sphingosine (SPH), which is
phosphorylated to form sphingosine-1-phosphate (S1P). Ceramide, SPH, and S1P are …

Sphingolipids represent a class of diverse bioactive lipid molecules that are increasingly
appreciated as key modulators of diverse physiologic and pathophysiologic processes that …

Abnormal sphingolipid metabolism has been previously reported in Alzheimer's disease
(AD). To extend these findings, several sphingolipids and sphingolipid hydrolases were …

Extracellular neuritic plaques, composed of aggregated amyloid-β (Aβ) peptides, are one of
the major histopathological hallmarks of Alzheimer's disease (AD), a progressive …

Sphingolipids have emerged as bioactive lipids involved in the regulation of many
physiological and pathological processes. In the retina, they have been established to …

The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and
ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular …

The mechanisms by which glucocorticoid receptor (GR) mediates glucocorticoid (GC)-
induced apoptosis are unknown. We studied the role of mitochondrial GR in this process …

Glucocorticoids (GC) are important in the regulation of selection and apoptosis of CD4+
CD8+ double-positive (DP) thymocytes. The pronounced GC-sensitivity of DP thymocytes …

Glucocorticoids (GC) induce apoptosis in a variety of cells, but their exact mode of action is
controversial. Although initiation relies on the GC receptor (GR) and de novo gene …

More than a quarter of a century ago, the phenomenon of glucocorticoid-induced apoptosis
in the majority of hematological cells was first recognized. More recently, glucocorticoid …