This review offers an update on research conducted with FinnTwin12 (FT12), the youngest
of the three Finnish Twin Cohorts. FT12 was designed as a two-stage study. In the first stage …

Monozygotic (MZ) twins and higher-order multiples arise when a zygote splits during pre-
implantation stages of development. The mechanisms underpinning this event have …

Twin samples allow to conduct a quasi-experimental co-twin case–control approach that can
control for genetic and environmental confounding in brain–cognition associations, being …

Tissue-specific mechanisms prompting obesity-related development complications in
humans remain unclear. We apply multiomics analyses of subcutaneous adipose tissue and …

Background Obesity is a heritable complex phenotype that can increase the risk of age‐
related outcomes. Biological age can be estimated from DNA methylation (DNAm) using …

Background Sleep bruxism (SB) and awake bruxism (AB) have been considered different
entities, although co‐occurrence between them has been shown. While genetic factors have …

Purpose Greater leisure-time physical activity (LTPA) associates with healthier lives, but
knowledge regarding occupational physical activity (OPA) is more inconsistent. DNA …

STUDY QUESTION Which genetic factors regulate female propensity for giving birth to
spontaneous dizygotic (DZ) twins? SUMMARY ANSWER We identified four new loci …

Background Sarcopenia, characterised by an accelerated loss of skeletal muscle mass and
function, is associated with negative outcomes. This study aimed to evaluate factors …

Abstract Background Metabolic syndrome (MetS) is associated with premature aging, but
whether this association is driven by genetic or lifestyle factors remains unclear. Methods …