Tissue niche influences immune and metabolic profiles to Staphylococcus aureus biofilm infection

Z Van Roy, P Arumugam, BP Bertrand… - Nature …, 2024 - nature.com
Infection is a devastating post-surgical complication, often requiring additional procedures
and prolonged antibiotic therapy. This is especially relevant for craniotomy and prosthetic …

Glutaminolysis is a Potential Therapeutic Target for Kidney Diseases

LP Ou, YJ Liu, ST Qiu, C Yang, JX Tang… - Diabetes, Metabolic …, 2024 - Taylor & Francis
Metabolic reprogramming contributes to the progression and prognosis of various kidney
diseases. Glutamine is the most abundant free amino acid in the body and participates in …

Metabolic homeostasis in fungal infections from the perspective of pathogens, immune cells, and whole-body systems

H Weerasinghe, H Stölting, AJ Rose… - … and Molecular Biology …, 2024 - journals.asm.org
The ability to overcome metabolic stress is a major determinant of outcomes during
infections. Pathogens face nutrient and oxygen deprivation in host niches and during their …

Echinocandin persistence directly impacts the evolution of resistance and survival of the pathogenic fungus Candida glabrata

A Arastehfar, F Daneshnia, DJ Floyd, NE Jeffries… - Mbio, 2024 - Am Soc Microbiol
Recent epidemiological studies documented an alarming increase in the prevalence of
echinocandin-resistant (ECR) Candida glabrata blood isolates. ECR isolates are known to …

Metabolic regulation of the host–fungus interaction: from biological principles to therapeutic opportunities

R Silva-Gomes, I Caldeira, R Fernandes, C Cunha… - 2024 - academic.oup.com
Fungal infections present a significant global public health concern, impacting over 1 billion
individuals worldwide and resulting in more than 3 million deaths annually. Despite …

Metabolic energetic adaptation of Atlantic salmon phagocytes to changes in carbon sources and exposure to PAMPs

D Ortiz, F Guajardo, A Talamilla-Espinoza… - Fish & Shellfish …, 2024 - Elsevier
Phagocytic cells are pivotal for host homeostasis and infection defense, necessitating
metabolic adaptations in glycolysis, the tricarboxylic acid (TCA) cycle, and oxidative …

Role of glutamine metabolism in tuberculosis pathogenesis: a mini review

S Parveen, WR Bishai - Frontiers in Tuberculosis, 2024 - frontiersin.org
Mycobacterium tuberculosis (Mtb) has remained one of the major infectious disease killers
for generations and generations. In 2023 alone, this ancient disease was responsible for the …

Produção, otimização e purificação de L-glutaminase de origem fúngica: revisão sistemática

SS do Nascimento… - …, 2023 - ojs.observatoriolatinoamericano …
A L-glutaminase é uma enzima multifuncional no aproveitamento industrial, principalmente
no melhoramento do sabor dos alimentos e apresenta inclinação para aplicação …