Clostridioides difficile infection: history, epidemiology, risk factors, prevention, clinical manifestations, treatment, and future options

S Di Bella, G Sanson, J Monticelli… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Clostridioides difficile infection (CDI) is one of the major issues in nosocomial infections.
This bacterium is constantly evolving and poses complex challenges for clinicians, often …

Efficacy, safety, and cost-effectiveness of bezlotoxumab in preventing recurrent Clostridioides difficile infection: systematic review and meta-analysis

MFH Mohamed, C Ward, A Beran… - Journal of Clinical …, 2024 - journals.lww.com
Methods: We performed a systematic review and meta-analysis to pool the rate of rCDI in
patients receiving BEZ and explore its efficacy and safety in preventing rCDI compared with …

Real-World Comparison of Bezlotoxumab to Standard of Care Therapy for Prevention of Recurrent Clostridioides difficile Infection in Patients at High Risk for …

TM Johnson, KC Molina, AH Howard… - Clinical Infectious …, 2022 - academic.oup.com
Background Bezlotoxumab (BEZ) is a monoclonal antibody used to prevent recurrent
Clostridioides difficile infection (rCDI). This study investigates BEZ effectiveness in relation to …

The Role of Bezlotoxumab for the Prevention of Recurrent Clostridioides difficile Infections: A Review of the Current Literature and Paradigm Shift after 2021

ML Hyte, LJ Arphai, CJ Vaughn, SH Durham - Antibiotics, 2022 - mdpi.com
Clostridioides difficile infections (CDIs), and particularly recurrent infections, cause a
significant burden on the health-care system. Bezlotoxumab is a new agent for the …

[PDF][PDF] The efficacy of bezlotoxumab in the prevention of recurrent Clostridium difficile: a systematic review

A Thandavaram, A Channar, A Purohit, B Shrestha… - Cureus, 2022 - cureus.com
Clostridium difficile infection (CDI) is the most common nosocomial infection in hospitals.
Despite the fact that CDI has treatment options, recurrence is common after the treatment …

Bezlotoxumab for Prevention of Recurrent Clostridioides difficile Infection With a Focus on Immunocompromised Patients

SF Askar, RM Kenney, Z Tariq… - Journal of …, 2023 - journals.sagepub.com
Objectives: Approximately 25% of patients with Clostridioides difficile infection (CDI) will
experience recurrence, which is greater in immunocompromised patients. We report …

Opportunities for antimicrobial stewardship interventions among solid organ transplant recipients

EJ Stohs, CA Gorsline - Infectious Disease Clinics, 2023 - id.theclinics.com
Antimicrobial stewardship is valuable to transplant programs to reduce the threat of
antimicrobial resistance, improve patient outcomes, and attenuate risks of drug toxicities. 1 …

[HTML][HTML] Therapeutics involved in managing initial and recurrent Clostridium difficile infection: An updated literature review

VK Nagesh, HHV Tran, D Elias… - World Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Clostridium difficile infection (CDI) has been increasing due to the effect of recurrent
hospitalizations. The use of antibiotics has been shown to alter the gut microbiome and lead …

[HTML][HTML] Efficacy of Bezlotoxumab Against Clostridioides difficile Infection: A Case-Series Study at a University Hospital in Japan and Literature Review

N Mori, J Hirai, N Asai, H Mikamo - Cureus, 2023 - ncbi.nlm.nih.gov
Background Clostridioides difficile infection (CDI) recurrence is a public health concern as
well as a health economic burden. Bezlotoxumab treatment is one way to prevent …

Comparative analysis and trends in liver transplant hospitalizations with Clostridium difficile infections: A 10‐year national cross‐sectional study

H Ali, P Patel, R Pamarthy, K Fatakhova… - Transplant Infectious …, 2022 - Wiley Online Library
Goals and background Clostridium difficile infection (CDI) is the leading cause of antibiotic‐
associated diarrhea in the United States. We aimed to determine comparative trends in …