Humans as diurnal beings are active during the day and rest at night. This daily oscillation of
behavior and physiology is driven by an endogenous circadian clock not environmental …

In this overview, we provide an update on recent progress made in understanding the
mechanisms of action, physiological functions, and roles in disease of retinoic acid related …

The circadian clock is a fundamental biological mechanism that orchestrates essential
cellular and physiological processes to optimize fitness and health. The basic functional unit …

MYCN activation is a hallmark of advanced neuroblastoma (NB) and a known master
regulator of metabolic reprogramming, favoring NB adaptation to its microenvironment. We …

The negative health effects of shift work, including carcinogenesis, may be mediated by
changes in DNA methylation, particularly in the circadian genes. Using the Infinium …

Abstract NF-Y is a CCAAT-binding trimeric transcription factor, whose regulome, interactome
and oncogenic potential point to direct involvement in cellular transformation. Yet little is …

The CCAAT box is recognized by the trimeric transcription factor NF-Y, whose NF-YA
subunit is present in two major splicing isoforms, NF-YAl (“long”) and NF-YAs (“short”). Little …

NF-Y is a trimeric transcription factor whose binding site-the CCAAT box-is enriched in
cancer-promoting genes. The regulatory subunit, the sequence-specificity conferring NF-YA …

Circadian clock genes influence biological processes and may be involved in
tumorigenesis. We systematically evaluated genetic variants in the circadian clock pathway …

Melatonin, noted for its anti-cancer properties in various malignancies, including cutaneous
melanoma, shows promise in Uveal melanoma (UM) treatment. This study aimed to evaluate …