The evolution of three decades of antiretroviral therapy: challenges, triumphs and the promise of the future
A Tseng, J Seet, EJ Phillips - British journal of clinical …, 2015 - Wiley Online Library
The evolution of human immunodeficiency virus (HIV) treatment has improved our
understanding and management of complex pharmacological issues that have driven …
understanding and management of complex pharmacological issues that have driven …
Pre-exposure prophylaxis for HIV prevention: safety concerns
RA Tetteh, BA Yankey, ET Nartey, M Lartey… - Drug safety, 2017 - Springer
Available evidence supports the efficacy of pre-exposure prophylaxis (PrEP) in decreasing
the incidence of human immunodeficiency virus (HIV) infection among high-risk individuals …
the incidence of human immunodeficiency virus (HIV) infection among high-risk individuals …
Historical development of vaginal microbicides to prevent sexual transmission of HIV in women: From past failures to future hopes
F Notario-Pérez, R Ruiz-Caro… - Drug design …, 2017 - Taylor & Francis
Infection with human immunodeficiency virus (HIV) remains a global public health concern
and is particularly serious in low-and middle-income countries. Widespread sexual violence …
and is particularly serious in low-and middle-income countries. Widespread sexual violence …
Genital tenofovir concentrations correlate with protection against HIV infection in the CAPRISA 004 trial: importance of adherence for microbicide effectiveness
ADM Kashuba, TN Gengiah, L Werner… - JAIDS Journal of …, 2015 - journals.lww.com
Objective: The CAPRISA 004 trial showed that coitally dosed tenofovir 1% gel reduced HIV
acquisition by 39% overall and 54% when used consistently. The objective of this analysis …
acquisition by 39% overall and 54% when used consistently. The objective of this analysis …
“Whatever is in the ARVs, is also in the PrEP” challenges associated with oral Pre-exposure prophylaxis use among female sex workers in South Africa
NF Makhakhe, Y Sliep, A Meyer-Weitz - Frontiers in Public Health, 2022 - frontiersin.org
Background The national policy on oral pre-exposure prophylaxis (PrEP) for female sex
workers (FSWs) was instituted in South Africa in 2016. FSWs were targeted for PrEP due to a …
workers (FSWs) was instituted in South Africa in 2016. FSWs were targeted for PrEP due to a …
Polyanionic carbosilane dendrimer-conjugated antiviral drugs as efficient microbicides: Recent trends and developments in HIV treatment/therapy
D Sepulveda-Crespo, R Gomez, FJ De La Mata… - … , Biology and Medicine, 2015 - Elsevier
Polyanionic carbosilane dendrimers (PCDs) are potential candidates for the development of
new microbicides for the prevention of HIV transmission. Tenofovir (TFV), which has dual …
new microbicides for the prevention of HIV transmission. Tenofovir (TFV), which has dual …
Triple combination of carbosilane dendrimers, tenofovir and maraviroc as potential microbicide to prevent HIV-1 sexual transmission
D Sepulveda-Crespo, J Sanchez-Rodriguez… - …, 2015 - Taylor & Francis
Aim: To research the synergistic activity by triple combinations of carbosilane dendrimers
with tenofovir and maraviroc as topical microbicide. Methods: Cytotoxicity, anti-HIV-1 activity …
with tenofovir and maraviroc as topical microbicide. Methods: Cytotoxicity, anti-HIV-1 activity …
Assessment of topical microbicides to prevent HIV-1 transmission: concepts, testing, lessons learned
DR Friend, PF Kiser - Antiviral research, 2013 - Elsevier
The development of topically applied products capable of preventing vaginal and rectal
transmission of HIV-1 has been on-going for nearly 20 years. Despite this, only one clinical …
transmission of HIV-1 has been on-going for nearly 20 years. Despite this, only one clinical …
The role of serpin and cystatin antiproteases in mucosal innate immunity and their defense against HIV
L Aboud, TB Ball, A Tjernlund… - American journal of …, 2014 - Wiley Online Library
Antiproteases play diverse roles in nature, from regulating protease activity to innate
defense against microorganisms. Recently, antiproteases have been shown to play …
defense against microorganisms. Recently, antiproteases have been shown to play …
Diarrhoea in children under five years of age in South Africa (1997–2014)
OF Awotiwon, V Pillay‐van Wyk… - Tropical Medicine & …, 2016 - Wiley Online Library
Objective To present evidence from available reliable published data on the prevalence,
incidence and severity of diarrhoea in children aged under five years in South Africa …
incidence and severity of diarrhoea in children aged under five years in South Africa …