V (D) J recombination: mechanisms of initiation

DG Schatz, PC Swanson - Annual review of genetics, 2011 - annualreviews.org
V (D) J recombination assembles immunoglobulin and T cell receptor genes during
lymphocyte development through a series of carefully orchestrated DNA breakage and …

Mechanism and control of V (D) J recombination versus class switch recombination: similarities and differences

DD Dudley, J Chaudhuri, CH Bassing, FW Alt - Advances in immunology, 2005 - Elsevier
Abstract V (D) J recombination is the process by which the variable region exons encoding
the antigen recognition sites of receptors expressed on B and T lymphocytes are generated …

RAG1 Core and V(D)J Recombination Signal Sequences Were Derived from Transib Transposons

VV Kapitonov, J Jurka - PLoS biology, 2005 - journals.plos.org
The V (D) J recombination reaction in jawed vertebrates is catalyzed by the RAG1 and
RAG2 proteins, which are believed to have emerged approximately 500 million years ago …

[HTML][HTML] Inhibitory actions of genistein in human breast cancer (MCF-7) cells

WF Chen, MH Huang, CH Tzang, M Yang… - Biochimica et Biophysica …, 2003 - Elsevier
Genistein, a natural isoflavanoid phytoestrogen, is thought to be the active ingredient in soy
that possesses breast cancer preventive properties. The molecular mechanisms that are …

The recombinase activating genes: architects of immune diversity during lymphocyte development

M Braams, K Pike-Overzet, FJT Staal - Frontiers in Immunology, 2023 - frontiersin.org
The mature lymphocyte population of a healthy individual has the remarkable ability to
recognise an immense variety of antigens. Instead of encoding a unique gene for each …

Role of recombination activating genes in the generation of antigen receptor diversity and beyond

M Nishana, SC Raghavan - Immunology, 2012 - Wiley Online Library
Summary V (D) J recombination is the process by which antibody and T‐cell receptor
diversity is attained. During this process, antigen receptor gene segments are cleaved and …

Regulation and Evolution of the RAG Recombinase

G Teng, DG Schatz - Advances in immunology, 2015 - Elsevier
The modular, noncontiguous architecture of the antigen receptor genes necessitates their
assembly through V (D) J recombination. This program of DNA breakage and rejoining …

The origins of the Rag genes—from transposition to V (D) J recombination

SD Fugmann - Seminars in immunology, 2010 - Elsevier
The recombination activating genes 1 and 2 (Rag1 and Rag2) encode the key enzyme that
is required for the generation of the highly diversified antigen receptor repertoire central to …

The bounty of RAGs: recombination signal complexes and reaction outcomes

PC Swanson - Immunological reviews, 2004 - Wiley Online Library
V (D) J recombination is a form of site‐specific DNA rearrangement through which antigen
receptor genes are assembled. This process involves the breakage and reunion of DNA …

Nonamer dependent RAG cleavage at CpGs can explain mechanism of chromosomal translocations associated to lymphoid cancers

AM Paranjape, SS Desai, M Nishana, U Roy… - PLoS …, 2022 - journals.plos.org
Chromosomal translocations are considered as one of the major causes of lymphoid
cancers. RAG complex, which is responsible for V (D) J recombination, can also cleave non …