MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies
MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …
Mechanisms that regulate the activities of TET proteins
K Joshi, S Liu, P Breslin SJ, J Zhang - Cellular and Molecular Life Sciences, 2022 - Springer
The ten–eleven translocation (TET) family of dioxygenases consists of three members,
TET1, TET2, and TET3. All three TET enzymes have Fe+ 2 and α-ketoglutarate (α-KG) …
TET1, TET2, and TET3. All three TET enzymes have Fe+ 2 and α-ketoglutarate (α-KG) …
Targeting IRG1 reverses the immunosuppressive function of tumor-associated macrophages and enhances cancer immunotherapy
Immune-responsive gene 1 (IRG1) encodes aconitate decarboxylase (ACOD1) that
catalyzes the production of itaconic acids (ITAs). The anti-inflammatory function of IRG1/ITA …
catalyzes the production of itaconic acids (ITAs). The anti-inflammatory function of IRG1/ITA …
TET2 guards against unchecked BATF3-induced CAR T cell expansion
Further advances in cell engineering are needed to increase the efficacy of chimeric antigen
receptor (CAR) and other T cell-based therapies,,,–. As T cell differentiation and functional …
receptor (CAR) and other T cell-based therapies,,,–. As T cell differentiation and functional …
Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses
As one of the most induced genes in activated macrophages, immune-responsive gene 1
(IRG1) encodes a mitochondrial metabolic enzyme catalysing the production of itaconic acid …
(IRG1) encodes a mitochondrial metabolic enzyme catalysing the production of itaconic acid …
TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
X Zhang, Y Zhang, C Wang, X Wang - Signal Transduction and …, 2023 - nature.com
Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
Redox signaling in drug-tolerant persister cells as an emerging therapeutic target
Drug-tolerant persister (DTP) cells have attracted significant interest, given their
predominant role in treatment failure. In this respect, DTP cells reportedly survive after …
predominant role in treatment failure. In this respect, DTP cells reportedly survive after …
The function and regulation of TET2 in innate immunity and inflammation
B Cong, Q Zhang, X Cao - Protein & cell, 2021 - academic.oup.com
TET2, a member of ten-eleven translocation (TET) family as α-ketoglutarate-and Fe2+-
dependent dioxygenase catalyzing the iterative oxidation of 5-methylcytosine (5mC), has …
dependent dioxygenase catalyzing the iterative oxidation of 5-methylcytosine (5mC), has …
Roles and regulations of TET enzymes in solid tumors
The mechanisms governing the methylome profile of tumor suppressors and oncogenes
have expanded with the discovery of oxidized states of 5-methylcytosine (5mC). Ten-eleven …
have expanded with the discovery of oxidized states of 5-methylcytosine (5mC). Ten-eleven …
Long non-coding RNA AFAP1-AS1 accelerates lung cancer cells migration and invasion by interacting with SNIP1 to upregulate c-Myc
Y Zhong, L Yang, F Xiong, Y He, Y Tang, L Shi… - … and Targeted Therapy, 2021 - nature.com
Actin filament associated protein 1 antisense RNA 1 (named AFAP1-AS1) is a long non-
coding RNA and overexpressed in many cancers. This study aimed to identify the role and …
coding RNA and overexpressed in many cancers. This study aimed to identify the role and …