Virus-mediated cell-cell fusion

H Leroy, M Han, M Woottum, L Bracq… - International Journal of …, 2020 - mdpi.com
Cell-cell fusion between eukaryotic cells is a general process involved in many
physiological and pathological conditions, including infections by bacteria, parasites, and …

High-risk oncogenic human cytomegalovirus

G Herbein - Viruses, 2022 - mdpi.com
Human cytomegalovirus (HCMV) is a herpesvirus that infects between 40% and 95% of the
population worldwide, usually without symptoms. The host immune response keeps the …

Structure-based design of a soluble human cytomegalovirus glycoprotein B antigen stabilized in a prefusion-like conformation

MR Sponholtz, PO Byrne, AG Lee… - Proceedings of the …, 2024 - pnas.org
Human cytomegalovirus (HCMV) glycoprotein B (gB) is a class III membrane fusion protein
required for viral entry. HCMV vaccine candidates containing gB have demonstrated …

Cytomegalovirus: shape-shifting the immune system

G Picarda, CA Benedict - The Journal of Immunology, 2018 - journals.aai.org
Abstract Systems-based based approaches have begun to shed light on extrinsic factors that
contribute to immune system variation. Among these, CMV (HHV-5, a β-herpesvirus) …

Modulation of innate and adaptive immunity by cytomegaloviruses

R Berry, GM Watson, S Jonjic… - Nature reviews …, 2020 - nature.com
The coordinated activities of innate and adaptive immunity are critical for effective protection
against viruses. To counter this, some viruses have evolved sophisticated strategies to …

Genomic and geographical structure of human cytomegalovirus

OJ Charles, C Venturini, S Gantt… - Proceedings of the …, 2023 - National Acad Sciences
Human cytomegalovirus (CMV) has infected humans since the origin of our species and
currently infects most of the world's population. Variability between CMV genomes is the …

Where do we stand after decades of studying human cytomegalovirus?

F Gugliesi, A Coscia, G Griffante, G Galitska… - Microorganisms, 2020 - mdpi.com
Human cytomegalovirus (HCMV), a linear double-stranded DNA betaherpesvirus belonging
to the family of Herpesviridae, is characterized by widespread seroprevalence, ranging …

Human cytomegalovirus in cancer: the mechanism of HCMV-induced carcinogenesis and its therapeutic potential

C Yu, S He, W Zhu, P Ru, X Ge… - Frontiers in Cellular and …, 2023 - frontiersin.org
Cancer is one of the leading causes of death worldwide. Human cytomegalovirus (HCMV), a
well-studied herpesvirus, has been implicated in malignancies derived from breast …

[HTML][HTML] Single-cell analysis of memory B cells from top neutralizers reveals multiple sites of vulnerability within HCMV Trimer and Pentamer

M Zehner, M Alt, A Ashurov, JA Goldsmith, R Spies… - Immunity, 2023 - cell.com
Human cytomegalovirus (HCMV) can cause severe diseases in fetuses, newborns, and
immunocompromised individuals. Currently, no vaccines are approved, and treatment …

Role of PDGF receptor-α during human cytomegalovirus entry into fibroblasts

K Wu, A Oberstein, W Wang… - Proceedings of the …, 2018 - National Acad Sciences
Human CMV (HCMV) exhibits a broad cell tropism that depends on two virion glycoprotein
complexes: a trimeric complex (gH/gL/gO) that facilitates viral infection primarily in …