Klotho was initially introduced as an antiaging molecule. Klotho deficiency significantly
reduces lifespan, and its overexpression extends it and protects against various pathological …

Klotho is an identified longevity gene with beneficial pleiotropic effects on the kidney.
Evidence shows that a decline in serum Klotho level occurs in early chronic kidney disease …

Rationale & Objective Most circulating biomarkers of chronic kidney disease (CKD)
progression focus on factors reflecting glomerular filtration. Few biomarkers capture …

Introduction Chronic kidney disease (CKD) is a silent disease. Most CKD patients are
unaware of their condition during the early stages of the disease which poses a challenge …

This study was designed to investigate the controversy on the potential role of sKlotho as an
early biomarker in Chronic Kidney Disease–Mineral Bone Disorder (CKD-MBD), to assess …

Hyperglycemic conditions (HG), at early stages of diabetic nephropathy (DN), cause a
decrease in podocyte numbers and an aberration of their function as key cells for glomerular …

Background Despite accumulating evidence of an association between air pollution and
renal disease, studies on the association between long-term exposure to air pollution and …

In the last decades, a significant increase in the incidence of diabetic kidney disease (DKD)
was observed concomitant with rising diabetes mellitus (DM) incidence. Kidney disease …

Background: In the past decade, researchers have been focused on discovering protein
biomarkers for diabetic kidney disease. This paper aims to search for, analyze, and …

Background The potential relationship between Klotho and cognitive function is limited and
controversial. This study aimed to quantify the association of Klotho and cognitive …