Dolutegravir resistance in sub-Saharan Africa: should resource-limited settings be concerned for future treatment?

D Kamori, G Barabona - Frontiers in Virology, 2023 - frontiersin.org
In sub-Saharan Africa (SSA) the burden of non-nucleoside reverse transcriptase inhibitor
(NNRTI) HIV drug resistance (HIVDR) has been high over the years. Therefore, in 2018 the …

Genetic features of HIV-1 integrase sub-subtype A6 predominant in Russia and predicted susceptibility to INSTIs

A Kirichenko, I Lapovok, P Baryshev… - Viruses, 2020 - mdpi.com
The increasing use of the integrase strand transfer inhibitor (INSTI) class for the treatment of
HIV-infection has pointed to the importance of analyzing the features of HIV-1 subtypes for …

Simplification to dual therapy containing lamivudine and raltegravir or dolutegravir in HIV-infected patients on virologically suppressive antiretroviral therapy

L Calza, V Colangeli, M Borderi, D Testi… - Journal of …, 2020 - academic.oup.com
Background Antiretroviral dual regimens including lamivudine and one boosted PI or
dolutegravir are warranted in order to optimize combination ART (cART), prevent long-term …

Primary resistance against integrase strand transfer inhibitors in integrase strand transfer inhibitor-naive patients failing first-and second-line ART in Tanzania

S Henerico, E Lyimo, AN Makubi… - Journal of …, 2022 - academic.oup.com
Abstract Introduction Sub-Saharan African countries are introducing integrase strand
transfer inhibitors (INSTIs) in their ART programmes as the preferred first-line regimen, and …

Impact of pre-existing drug resistance on risk of virological failure in South Africa

JZ Li, N Stella, MC Choudhary, A Javed… - Journal of …, 2021 - academic.oup.com
Objectives There is conflicting evidence on the impact of pre-existing HIV drug resistance
mutations (DRMs) in patients infected with non-B subtype virus. Methods We performed a …

Low level of HIV-1C integrase strand transfer inhibitor resistance mutations among recently diagnosed ART-naive Ethiopians

M Kiros, DA Tefera, H Andualem, A Geteneh… - Scientific Reports, 2023 - nature.com
With the widespread use of Integrase strand transfer inhibitors (INSTIs), surveillance of HIV-
1 pretreatment drug resistance is critical in optimizing antiretroviral treatment efficacy …

Pretreatment HIV drug resistance among adults initiating or re-initiating first-line antiretroviral therapy in Zimbabwe: fast-tracking the transition to dolutegravir-based …

V Kouamou, J Mavetera, J Manasa… - AIDS Research and …, 2021 - liebertpub.com
Pretreatment drug resistance (PDR) can compromise antiretroviral therapy (ART) efficacy
and undermine the WHO targets to end the AIDS epidemic as a public health threat by 2030 …

[HTML][HTML] First report of computational protein–ligand docking to evaluate susceptibility to HIV integrase inhibitors in HIV-infected Iranian patients

F Ghasabi, A Hashempour, N Khodadad… - … and Biophysics Reports, 2022 - Elsevier
Background Iran has recently included integrase (INT) inhibitors (INTIs) in the first‐line
treatment regimen in human immunodeficiency virus (HIV)-infected patients. However, there …

Comprehensive Analysis of HIV-1 Integrase Resistance-Related Mutations in African Countries

F Branda, M Giovanetti, L Sernicola, S Farcomeni… - Pathogens, 2024 - mdpi.com
The growing emergence of non-nucleoside reverse transcriptase inhibitor (NNRTI) HIV drug
resistance in sub-Saharan Africa (SSA) led to the World Health Organization (WHO) …

Structural comparison of diverse Hiv-1 subtypes using molecular modelling and docking analyses of integrase inhibitors

D Isaacs, SG Mikasi, AE Obasa, GM Ikomey… - Viruses, 2020 - mdpi.com
The process of viral integration into the host genome is an essential step of the HIV-1 life
cycle. The viral integrase (IN) enzyme catalyzes integration. IN is an ideal therapeutic …