Background: Molecules secreted by Trypanosoma cruzi (T. cruzi) have beneficial effects on
the immune system and can fight against cancer by inhibiting the growth of tumor cells …

Trypanosoma brucei, Leishmania spp., and T. cruzi are flagellate protozoans of the family
Trypanosomatidae and the causative agents of human African trypanosomiasis …

Desialylation is a pivotal part of sialic acid metabolism, which initiates the catabolism of
glycans by removing the terminal sialic acid residues on glycans, thereby modulating the …

Aims From well-delimited immunomodulatory, redox and antimicrobial properties;
metronidazole and eugenol were used as structural platforms to assembly two new …

Diseases caused by several (sub) species of parasites from the genus Trypanosoma are a
major concern for public and animal health. Trypanosomes have a digenetic life cycle that …

The synthesis of the O-3 triazole-linked galactosyl arylsulfonamides 1–7 as potential
inhibitors of Trypanosoma cruzi cell invasion is described. These target compounds were …

B-1 cells can directly and indirectly influence the immune response. These cells are known
to be excellent producers of natural antibodies and can secrete a variety of …

Trypanosoma cruzi P21 protein (P21) is a putative secreted and immunomodulatory
molecule with potent bioactive properties such as induction of phagocytosis and actin …

Complement is an essential element in both innate and acquired immunity contributing to
the immunopathogenesis of many disorders, including Chagas Disease (CD). Human …

Background Chagas is a neglected tropical disease caused by the protozoan parasite
Trypanosoma cruzi. On the order of seven million people are infected worldwide and current …