The rapid emergence of antifungal-resistant human-pathogenic fungi

SR Lockhart, A Chowdhary, JAW Gold - Nature Reviews Microbiology, 2023 - nature.com
During recent decades, the emergence of pathogenic fungi has posed an increasing public
health threat, particularly given the limited number of antifungal drugs available to treat …

Aspergillus fumigatus and Aspergillosis in 2019

JP Latgé, G Chamilos - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Aspergillus fumigatus is a saprotrophic fungus; its primary habitat is the soil. In its ecological
niche, the fungus has learned how to adapt and proliferate in hostile environments. This …

The evolutionary origins of pesticide resistance

NJ Hawkins, C Bass, A Dixon, P Neve - Biological Reviews, 2019 - Wiley Online Library
Durable crop protection is an essential component of current and future food security.
However, the effectiveness of pesticides is threatened by the evolution of resistant …

The global problem of antifungal resistance: prevalence, mechanisms, and management

DS Perlin, R Rautemaa-Richardson… - The Lancet infectious …, 2017 - thelancet.com
All serious fungal infections need appropriate antifungal therapy for successful patient
outcome. Only a few classes of antifungal drugs are available, so the emergence of …

Practice guidelines for the diagnosis and management of aspergillosis: 2016 update by the Infectious Diseases Society of America

TF Patterson, GR Thompson III… - Clinical infectious …, 2016 - academic.oup.com
It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …

Mechanisms of antifungal drug resistance

LE Cowen, D Sanglard… - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
Antifungal therapy is a central component of patient management for acute and chronic
mycoses. Yet, treatment choices are restricted because of the sparse number of antifungal …

The evolution of fungicide resistance

JA Lucas, NJ Hawkins, BA Fraaije - Advances in applied microbiology, 2015 - Elsevier
Fungicides are widely used in developed agricultural systems to control disease and
safeguard crop yield and quality. Over time, however, resistance to many of the most …

Alarming India‐wide phenomenon of antifungal resistance in dermatophytes: a multicentre study

A Ebert, M Monod, K Salamin, A Burmester, S Uhrlaß… - Mycoses, 2020 - Wiley Online Library
Background An alarming increase in recalcitrant dermatophytosis has been witnessed in
India over the past decade. Drug resistance may play a major role in this scenario …

Fungal infections in animals: a patchwork of different situations

S Seyedmousavi, SMG Bosco, S De Hoog… - Medical …, 2018 - academic.oup.com
The importance of fungal infections in both human and animals has increased over the last
decades. This article represents an overview of the different categories of fungal infections …

The fungal CYP51s: their functions, structures, related drug resistance, and inhibitors

J Zhang, L Li, Q Lv, L Yan, Y Wang… - Frontiers in microbiology, 2019 - frontiersin.org
CYP51 (Erg11) belongs to the cytochrome P450 monooxygenase (CYP) superfamily and
mediates a crucial step of the synthesis of ergosterol, which is a fungal-specific sterol. It is …