Triazole derivatives and their anti-tubercular activity

S Zhang, Z Xu, C Gao, QC Ren, L Chang, ZS Lv… - European journal of …, 2017 - Elsevier
Tuberculosis (TB) remains one of the most widespread and leading deadliest diseases,
threats one-third of the world's population. Although numerous efforts have been undertaken …

Emerging impact of triazoles as anti-tubercular agent

A Sharma, AK Agrahari, S Rajkhowa… - European Journal of …, 2022 - Elsevier
Tuberculosis, a disease of poverty is a communicable infection with a reasonably high
mortality rate worldwide. 10 Million new cases of TB were reported with approx 1.4 million …

Drug discovery in tuberculosis. New drug targets and antimycobacterial agents

A Campaniço, R Moreira, F Lopes - European journal of medicinal …, 2018 - Elsevier
Tuberculosis (TB) remains a major health problem worldwide. The infectious agent,
Mycobacterium tuberculosis, has a unique ability to survive within the host, alternating …

Recent Advances of DprE1 Inhibitors against Mycobacterium tuberculosis: Computational Analysis of Physicochemical and ADMET Properties

PSM Amado, C Woodley, MLS Cristiano, PM O'Neill - ACS omega, 2022 - ACS Publications
Decaprenylphosphoryl-β-d-ribose 2′-epimerase (DprE1) is a critical flavoenzyme in
Mycobacterium tuberculosis, catalyzing a vital step in the production of lipoarabinomannan …

Cell wall: A versatile fountain of drug targets in Mycobacterium tuberculosis

ZS Bhat, MA Rather, M Maqbool, HUL Lah… - Biomedicine & …, 2017 - Elsevier
Tuberculosis is the leading infectious disease responsible for an estimated one and a half
million human deaths each year around the globe. HIV-TB coinfection and rapid increase in …

Thia‐Michael Addition: An Emerging Strategy in Organic Synthesis

P Wadhwa, A Kharbanda… - Asian Journal of Organic …, 2018 - Wiley Online Library
The thia‐Michael addition reaction has been demonstrated to be a highly powerful tool in
organic synthesis. Indeed, the influential nature of this reaction has been well‐established in …

Recent advancements and developments in search of anti-tuberculosis agents: a quinquennial update and future directions

TM Dhameliya, KA Bhakhar, ND Gajjar, KA Patel… - Journal of Molecular …, 2022 - Elsevier
Tuberculosis (TB) has been considered as the highly chronic, contagious and infectious
disorder caused by Mycobacterium tuberculosis (Mtb). Every year more than 10 million …

Promiscuous targets for antitubercular drug discovery: The paradigm of DprE1 and MmpL3

G Degiacomi, JM Belardinelli, MR Pasca, E De Rossi… - Applied Sciences, 2020 - mdpi.com
The development and spread of Mycobacterium tuberculosis multi-drug resistant strains still
represent a great global health threat, leading to an urgent need for novel anti-tuberculosis …

Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery

E Azzali, D Machado, A Kaushik… - Journal of medicinal …, 2017 - ACS Publications
Tuberculosis remains one of the deadliest infectious diseases in the world, and the
increased number of multidrug-resistant and extremely drug-resistant strains is a significant …

DprE1 inhibitors: enduring aspirations for future antituberculosis drug discovery

S Yadav, A Soni, O Tanwar, R Bhadane… - …, 2023 - Wiley Online Library
DprE1 is a crucial enzyme involved in the cell wall synthesis of Mycobacterium tuberculosis
and a promising target for antituberculosis drug development. However, its unique structural …