Integrins mediate cell adhesion to extracellular matrix and transduce signals bidirectionally
across the membrane. Integrin α V β 3 has been shown to play an essential role in tumor …

We highlight recent progress in understanding cadherin and integrin function in the model
organism Drosophila. New functions for these adhesion receptors continue to be discovered …

Presynaptic homeostatic plasticity (PHP) adaptively regulates synaptic transmission in
health and disease. Despite identification of numerous genes that are essential for PHP, we …

Pulsatile actomyosin contractility, important in tissue morphogenesis, has been studied
mainly in apical but less in basal domains. Basal myosin oscillation underlying egg chamber …

Regulated assembly and disassembly, or turnover, of integrin-mediated cell–extracellular
matrix (ECM) adhesions is essential for dynamic cell movements and long-term tissue …

Establishment of intercellular interactions between various cell types of different origin is
vital for organism development and tissue maintenance. Therefore, precise timing …

Talin serves an essential function during integrin-mediated adhesion in linking integrins to
actin via the intracellular adhesion complex. In addition, the N-terminal head domain of talin …

Cell adhesion to the extracellular matrix (ECM) allows cells to form and maintain three-
dimensional tissue architecture. Cell–ECM adhesions are stabilized upon exposure to …

Melanoblasts disperse throughout the skin and populate hair follicles through long-range
cell migration. During migration, cells undergo cycles of coordinated attachment and …

Integrins are heterodimeric adhesion receptors that link the extracellular matrix (ECM) to the
cytoskeleton. Binding of the scaffold protein, talin, to the cytoplasmic tail of β-integrin causes …