Recent developments in ultralarge and structure-based virtual screening approaches
C Gorgulla - Annual Review of Biomedical Data Science, 2023 - annualreviews.org
Drug development is a wide scientific field that faces many challenges these days. Among
them are extremely high development costs, long development times, and a small number of …
them are extremely high development costs, long development times, and a small number of …
Paving new roads toward the advancement of broad‐spectrum antiviral agents
R Du, JG Achi, Q Cui, L Rong - Journal of Medical Virology, 2024 - Wiley Online Library
Broad‐spectrum antivirals (BSAs) have the advantageous property of being effective against
a wide range of viruses with a single drug, offering a promising therapeutic solution for the …
a wide range of viruses with a single drug, offering a promising therapeutic solution for the …
Identification of Protein–Protein Interaction Associated Functions Based on Gene Ontology
Protein–protein interactions (PPIs) involve the physical or functional contact between two or
more proteins. Generally, proteins that can interact with each other always have special …
more proteins. Generally, proteins that can interact with each other always have special …
Homo cerevisiae—Leveraging Yeast for Investigating Protein–Protein Interactions and Their Role in Human Disease
Understanding how genetic variation affects phenotypes represents a major challenge,
particularly in the context of human disease. Although numerous disease-associated genes …
particularly in the context of human disease. Although numerous disease-associated genes …
Benchmark and optimization of AlphaFold structures based virtual screening strategy
Y Peng, X Wu, L Lin, Z Deng, L Zhao, H Ke - bioRxiv, 2023 - biorxiv.org
Recent advancements in artificial intelligence such as AlphaFold, have enabled more
accurate prediction of protein three-dimensional structure from amino acid sequences. This …
accurate prediction of protein three-dimensional structure from amino acid sequences. This …
Interactome and structural basis for targeting the human T-cell leukemia virus Tax oncoprotein
Human T-cell leukemia virus type-1 (HTLV-1) is the first pathogenic retrovirus discovered in
human. Although HTLV-1-induced diseases are well characterized and linked to the …
human. Although HTLV-1-induced diseases are well characterized and linked to the …