The RAF/MEK/ERK signaling pathway regulates diverse cellular processes as exemplified
by cell proliferation, differentiation, motility, and survival. Activation of ERK1/2 generally …

The Ras/Raf/extracellular signal‐regulated kinase (ERK) signaling pathway plays a crucial
role in almost all cell functions and therefore requires exquisite control of its spatiotemporal …

Despite recent advances in understanding molecular mechanisms involved in glioblastoma
progression, the prognosis of the most malignant brain tumor continues to be dismal …

Gold (III) compounds have long been investigated for anti-cancer treatment. However,
clinical use has often been hampered by their poor stability in solution. A reduction of gold …

OBJECTIVE: To investigate the effect of vitrification and beta-mercaptoethanol (β-ME) on
reactive oxygen species (ROS) activity and in vitro development of oocytes vitrified before or …

In order to elucidate the role of the mitogen-activated protein kinases, including JNK, p38
MAPK and ERK, as well as the survival-associated PI3K/Akt signaling pathway, in the …

The long-term clinical usefulness of doxorubicin (DOX), an anthracycline with potent
antitumor activity, is limited by DOX-induced cardiotoxicity. Kaempferol, one of the most …

Stem cell-based therapy has emerged as an attractive method for regenerating and
repairing the lost heart organ. On other hand, poor survival and maintenance of the cells …

We previously showed that C-phycocyanin (PC), an antioxidant biliprotein pigment of
Spirulina platensis (a blue-green alga), effectively inhibited doxorubicin-induced oxidative …

Epidemiological studies have shown positive preventive action of flavonoids on
cardiovascular and neurodegenerative events. Among the six groups in which flavonoids …