Testing spasticity mechanisms in chronic stroke before and after intervention with contralesional motor cortex 1 Hz rTMS and physiotherapy

W Mahmoud, H Hultborn, J Zuluaga, C Zrenner… - Journal of …, 2023 - Springer
Background Previous studies showed that repetitive transcranial magnetic stimulation
(rTMS) reduces spasticity after stroke. However, clinical assessments like the modified …

Post‐activation depression from primary afferent depolarization (PAD) produces extensor H‐reflex suppression following flexor afferent conditioning

K Metz, IC Matos, K Hari, O Bseis… - The Journal of …, 2023 - Wiley Online Library
Suppression of the extensor H‐reflex by flexor afferent conditioning is thought to be
produced by a long‐lasting inhibition of extensor Ia afferent terminals via GABAA receptor …

Modulation of sensory input to the spinal cord: Contribution of focal epidural polarization and of GABA released by interneurons and glial cells

I Hammar, E Jankowska - European Journal of Neuroscience, 2024 - Wiley Online Library
Modulation of input from primary afferent fibres has long been examined at the level of the
first relays of these fibres. However, recent studies reveal that input to the spinal cord may …

Pharmacological blocking of spinal GABAA receptors in monkeys reduces sensory transmission to the spinal cord, thalamus, and cortex

AA Mahrous, L Liang, JM Balaguer, JC Ho, EM Grigsby… - Cell reports, 2025 - cell.com
A century of research established that GABA inhibits proprioceptive inputs presynaptically to
sculpt spinal neural inputs into skilled motor output. Recent results in mice challenged this …

Effect of muscle length on the modulation of H-reflex and inhibitory mechanisms of Ia afferent discharges during passive muscle lengthening

J Colard, M Jubeau, M Crouzier… - Journal of …, 2024 - journals.physiology.org
The effectiveness of activated Ia afferents to discharge α-motoneurons is decreased during
passive muscle lengthening compared with static and shortening muscle conditions …

[HTML][HTML] 10 kHz spinal cord stimulation improves metrics of spinal sensory processing in a male STZ rat model of diabetes

D Wang, KY Lee, D Lee, ZB Kagan, K Bradley - Neuroscience Letters, 2024 - Elsevier
To explore why clinical 10 kHz spinal cord stimulation (10 kHz SCS) might improve
neurological function in a model of painful diabetic neuropathy (PDN), the short-term …

Skin and not dorsal root stimulation reduces hypertonus in thoracic motor complete spinal cord injury: a single case report

B Lieu, DG Everaert, C Ho… - Journal of …, 2024 - journals.physiology.org
On demand and localized treatment for excessive muscle tone after spinal cord injury (SCI)
is currently not available. Here, we examine the reduction in leg hypertonus in a person with …

GABA Increases Sensory Transmission In Monkeys

AA Mahrous, L Liang, JM Balaguer, JC Ho, K Hari… - BioRxiv, 2023 - biorxiv.org
Sensory input flow is central to voluntary movements. For almost a century, GABA was
believed to modulate this flow by inhibiting sensory axons in the spinal cord to sculpt neural …

Understanding Age-Related Changes in Proprioception through Active and Passive Tasks

E Carranza, S Franovic, A Boos, E Pirondini - bioRxiv, 2023 - biorxiv.org
Voluntary control of motor actions requires precise regulation of proprioceptive and
somatosensory functions. While aging has demonstrated to decline sensory processing …

Modulation of input to the spinal cord; contribution of GABA released by interneurons and glial cells by polarization at the entry of sensory information

E Jankowska, I Hammar - bioRxiv, 2024 - biorxiv.org
Modulation of input from primary afferent fibres has long been examined at the level of the
first relay neurons of these fibres. However, recent studies reveal that input to the spinal cord …