The ability to split one cell into two is fundamental to all life, and many bacteria can
accomplish this feat several times per hour with high accuracy. Most bacteria call on an …

The importance of the cell wall to the viability of the bacterium is underscored by the breadth
of antibiotic structures that act by blocking key enzymes that are tasked with cell-wall …

Bacterial cell division is mediated by the divisome which is organized by the Z ring, a
cytoskeletal element formed by the polymerization of the tubulin homologue FtsZ. Despite …

The FtsZ protein is a highly conserved bacterial tubulin homolog. In vivo, the functional form
of FtsZ is the polymeric, ring-like structure (Z-ring) assembled at the future division site …

Bacterial cell division is initiated by the midcell assembly of polymers of the tubulin-like
GTPase FtsZ. The FtsZ ring (Z-ring) is a discontinuous structure made of dynamic patches of …

Despite the central role of division in bacterial physiology, how division proteins work
together as a nanoscale machine to divide the cell remains poorly understood. Cell division …

Intrinsically disordered regions (IDRs) can function as autoregulators of folded enzymes to
which they are tethered. One example is the bacterial cell division protein FtsZ. This includes …

Antimicrobial resistance to virtually all clinically applied antibiotic classes severely limits the
available options to treat bacterial infections. Hence, there is an urgent need to develop and …

Treadmilling protein filaments perform essential cellular functions by growing from one end
while shrinking from the other, driven by nucleotide hydrolysis. Bacterial cell division relies …

Acinetobacter baumannii is a pathogen with high intrinsic antimicrobial resistance while
multidrug resistant (MDR) and extensively drug resistant (XDR) strains of this pathogen are …