High-throughput screening for optimizing adoptive T cell therapies

Y Zhang, Q Xu, Z Gao, H Zhang, X Xie, M Li - Experimental Hematology & …, 2024 - Springer
Adoptive T cell therapy is a pivotal strategy in cancer immunotherapy, demonstrating potent
clinical efficacy. However, its limited durability often results in primary resistance. High …

Parsing digital or analog TCR performance through piconewton forces

A Akitsu, E Kobayashi, Y Feng, HM Stephens… - Science …, 2024 - science.org
αβ T cell receptors (TCRs) principally recognize aberrant peptides bound to major
histocompatibility complex molecules (pMHCs) on unhealthy cells, amplifying specificity and …