Comprehensive Profiling and Therapeutic Insights into Differentially Expressed Genes in Hepatocellular Carcinoma

WL Caputo, MC de Souza, CR Basso, VA Pedrosa… - Cancers, 2023 - mdpi.com
Simple Summary Hepatocellular carcinoma remains crucial due to its high prevalence and
the need for improved understanding and treatment options. This study utilizes extensive …

Systems-level identification of key transcription factors in immune cell specification

C Liu, K Omilusik, C Toma, NS Kurd… - PLOS Computational …, 2022 - journals.plos.org
Transcription factors (TFs) are crucial for regulating cell differentiation during the
development of the immune system. However, the key TFs for orchestrating the specification …

High expression of E2F4 is an adverse prognostic factor and related to immune infiltration in oral squamous cell carcinoma

Y Zheng, H Fei - BioMed Research International, 2022 - Wiley Online Library
Background. We aimed to evaluate the prognostic value of E2F4 expression in oral
squamous cell carcinoma (OSCC) and clarify its influence on immune cell infiltration and …

Dopamine and dopamine receptor D1 as a novel favourable biomarker for hepatocellular carcinoma

Z Wang, P Wen, B Hu, S Cao, X Shi, W Guo… - Cancer Cell …, 2021 - Springer
Background Hepatocellular carcinoma (HCC) remains one of the most common malignant
tumours worldwide. Therefore, the identification and development of sensitivity-genes as …

Integrative analysis reveals the potential role and prognostic value of GOLM1 in hepatocellular carcinoma

Y Lin, Z He, X Gao, L Lu, C Lu, J Huang… - Oxidative Medicine …, 2022 - Wiley Online Library
Overexpression of Golgi membrane protein 1 (GOLM1) is closely associated with
hepatocellular carcinoma (HCC) vascular invasion. How GOLM1 may be involved in …

[HTML][HTML] Transcription factor E2F4 facilitates SUMOylation to promote HCC progression through interaction with LIN9

Z Ma, Q Li, W Wang, Z Deng - … Journal of Oncology, 2024 - spandidos-publications.com
SUMOylation plays a crucial role in numerous cellular biological and pathophysiological
processes associated with human disease; however, the mechanisms regulating the genes …

CDK1-SRC Interaction-Dependent Transcriptional Activation of HSP90AB1 Promotes Antitumor Immunity in Hepatocellular Carcinoma

YJ Zhang, DH Yi - Journal of Proteome Research, 2023 - ACS Publications
This study aimed to analyze multiomics data and construct a regulatory network involving
kinases, transcription factors, and immune genes in hepatocellular carcinoma (HCC) …

DeepCG: A cell graph model for predicting prognosis in lung adenocarcinoma

B Zhang, C Li, J Wu, J Zhang… - International journal of …, 2024 - Wiley Online Library
Lung cancer is the first leading cause of cancer‐related death in the United States, with lung
adenocarcinoma as the major subtype accounting for 40% of all cases. To improve patient …

Uncovering novel roles of miR-122 in the pathophysiology of the liver: Potential interaction with NRF1 and E2F4 signaling

M Paluschinski, J Schira-Heinen, R Pellegrino, LR Heij… - Cancers, 2023 - mdpi.com
Simple Summary The microRNA miR-122 plays a crucial role in liver function, but its full
impact on gene regulation and disease mechanisms remains unclear. To better understand …

[HTML][HTML] Transcriptomic Analysis of HPV-Positive Oesophageal Tissue Reveals Upregulation of Genes Linked to Cell Cycle and DNA Replication

MO Shafiq, MO Cakir, U Bilge, Y Pasha… - … Journal of Molecular …, 2024 - pmc.ncbi.nlm.nih.gov
Human papillomavirus (HPV) is a prevalent sexually transmitted infection, implicated in
various cancers, yet its influence in non-cancerous oesophageal tissue remains unclear …