Annexin A2 is a calcium-dependent, phospholipid-binding protein found on various cell
types. It is up-regulated in various tumor types and plays multiple roles in regulating cellular …

Cathepsin B is a lysosomal cysteine protease in normal cells and tissues. In malignant
tumors and premalignant lesions, the expression of cathepsin B is highly upregulated and …

The identification of circulating tumor antigens or their related autoantibodies provides a
means for early cancer diagnosis as well as leads for therapy. The purpose of this study was …

One of the most life‐threatening complications of prostate cancer is skeletal metastasis. In
order to develop treatment for metastasis, it is important to understand its molecular …

Annexin A2 (ANXA2) orchestrates multiple biologic processes and clinical associations,
especially in cancer progression. The structure of ANXA2 affects its cellular localization and …

To study potential roles of plasma membrane-associated extracellular cathepsin B in tumor
cell invasion and metastasis, we used the yeast two-hybrid system to screen for proteins that …

The cysteine protease cathepsin B is upregulated in a variety of tumors, particularly at the
invasive edges. Cathepsin B can degrade extracellular matrix proteins, such as collagen IV …

Tenascin C (TNC) is a component of the provisional extracellular matrix (ECM) that
characterizes solid tumours. Cell surface annexin II is a high‐affinity receptor for large TNC …

Despite improvements in treatment of patients with head and neck squamous cell carcinoma
(HNSCC) over the last two decades, the survival rate of these patients has not increased …

Introduction 3. Cellular plasminogen regulation 3.1. Structure and function of plasminogen
3.2. Activation of plasminogen 4. Observations from model systems that define the role of …