Mitochondria retain bacterial traits due to their endosymbiotic origin, but host cells do not
recognize them as foreign because the organelles are sequestered. However, the regulated …

Sepsis is a severe medical condition characterized by a systemic inflammatory response,
often culminating in multiple organ dysfunction and high mortality rates. In recent years …

Mitochondrial dysfunction plays a pivotal role in the pathogenesis of Parkinson's disease
(PD). As a mitochondrial governor, voltage-dependent anion channel 1 (VDAC1) is critical …

New generation of nanomaterials with organelle‐level precision provide significant promise
for targeted attacks on mitochondria, exhibiting remarkable therapeutic potency. Here, we …

Cristae membrane state plays a central role in regulating mitochondrial function and cellular
metabolism. The protein Optic atrophy 1 (Opa1) is an important crista remodeler that exists …

Abnormal cellular apoptosis plays a pivotal role in the pathogenesis of Multiple Myeloma
(MM). Over the years, BCL-2, a crucial anti-apoptotic protein, has garnered significant …

Mitochondria, traditionally recognized as cellular'powerhouses' due to their pivotal role in
energy production, have emerged as multifunctional organelles at the intersection of …

Mitochondria are central to cellular energy production, and their dysfunction is a major
contributor to oxidative stress and chronic inflammation, pivotal factors in aging, and related …

The redox-active protein cytochrome c is a highly positively charged hemoglobin that
regulates cell fate decisions of life and death. Under normal physiological conditions …

Mitochondrial Ca2+ overload can mediate mitochondria-dependent cell death, a major
contributor to several human diseases. Indeed, Duchenne muscular dystrophy (MD) is …