HLA-G: an immune checkpoint molecule

ED Carosella, N Rouas-Freiss, D Tronik-Le Roux… - Advances in …, 2015 - Elsevier
HLA-G is a molecule that was first known to confer protection to the fetus from destruction by
the immune system of its mother, thus critically contributing to fetal–maternal tolerance. The …

Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association

EA Donadi, EC Castelli, A Arnaiz-Villena… - Cellular and molecular …, 2011 - Springer
The HLA-G gene displays several peculiarities that are distinct from those of classical HLA
class I genes. The unique structure of the HLA-G molecule permits a restricted peptide …

The genetic structure of 3′ untranslated region of the HLA-G gene: polymorphisms and haplotypes

EC Castelli, CT Mendes-Junior, NHS Deghaide… - Genes & …, 2010 - nature.com
The HLA-G gene is predominantly expressed at the maternal–fetal interface. It has been
associated with maternal–fetal tolerance and in the inhibition of cytotoxic T lymphocyte and …

Insights into HLA-G Genetics Provided by Worldwide Haplotype Diversity

EC Castelli, J Ramalho, IOP Porto, THA Lima… - Frontiers in …, 2014 - frontiersin.org
Human leukocyte antigen G (HLA-G) belongs to the family of non-classical HLA class I
genes, located within the major histocompatibility complex (MHC). HLA-G has been the …

A Comprehensive Study of Polymorphic Sites along the HLA-G Gene: Implication for Gene Regulation and Evolution

EC Castelli, CT Mendes-Junior… - Molecular biology …, 2011 - academic.oup.com
HLA-G molecule plays an important role on immune response regulation and has been
implicated on the inhibition of T and natural killer cell cytolytic function and inhibition of …

HLA‐G: Function, polymorphisms and pathology

A Arnaiz‐Villena, I Juarez… - International Journal …, 2021 - Wiley Online Library
HLA‐G immune modulatory genes and molecules are presently being studied by a
widespread number of research groups. In the present study, we do not aim to be exhaustive …

In silico analysis of microRNAS targeting the HLA-G 3′ untranslated region alleles and haplotypes

EC Castelli, P Moreau, AO e Chiromatzo… - Human immunology, 2009 - Elsevier
It has been reported that microRNAs (miRNA) may have allele-specific targeting for the 3′
untranslated region (3′ UTR) of the HLA-G locus. In a previous study, we reported 11 3 …

Worldwide genetic variation at the 3′ untranslated region of the HLA-G gene: balancing selection influencing genetic diversity

A Sabbagh, P Luisi, EC Castelli, L Gineau… - Genes & …, 2014 - nature.com
The HLA-G (human leukocyte antigen-G) molecule plays a pivotal role in immune tolerance
by inhibiting different cell subsets involved in both innate and adaptive immunity. Besides its …

The Role of HLA-G Molecule and HLA-G Gene Polymorphisms in Tumors, Viral Hepatitis, and Parasitic Diseases

FC Dias, EC Castelli, CVA Collares, P Moreau… - Frontiers in …, 2015 - frontiersin.org
Considering that the non-classical HLA-G molecule has well-recognized tolerogenic
properties, HLA-G expression is expected to be deleterious when present in tumor cells and …

Human leukocyte antigen-G (HLA-G) polymorphism and expression in breast cancer patients

S Jeong, S Park, BW Park, Y Park, OJ Kwon, HS Kim - PLoS One, 2014 - journals.plos.org
Human leukocyte antigen-G (HLA-G) is known to be implicated in a tumor-driven immune
escape mechanism in malignancies. The purpose of this study was to investigate HLA-G …