Lessons from the crystallographic analysis of small molecule binding to human serum albumin

S Curry - Drug metabolism and pharmacokinetics, 2009 - jstage.jst.go.jp
Human serum albumin (HSA) is an abundant and highly soluble plasma protein with the
capacity to bind a remarkably diverse set of lipophilic anionic compounds so that it fulfils …

Novel insights into the pleiotropic effects of human serum albumin in health and disease

CE Ha, NV Bhagavan - Biochimica et Biophysica Acta (BBA)-General …, 2013 - Elsevier
Background Human serum albumin is the principal protein in human serum. It participates in
regulation of plasma oncotic pressure and transports endogenous and exogenous ligands …

Location of high and low affinity fatty acid binding sites on human serum albumin revealed by NMR drug-competition analysis

JR Simard, PA Zunszain, JA Hamilton… - Journal of molecular …, 2006 - Elsevier
Human serum albumin (HSA) is an abundant plasma protein that transports a wide variety of
drugs and endogenous compounds. The complex binding capacity of HSA has made it a …

[HTML][HTML] Crystallographic analysis of human serum albumin complexed with 4Z, 15E-bilirubin-IXα

PA Zunszain, J Ghuman, AF McDonagh… - Journal of molecular …, 2008 - Elsevier
Bilirubin, an insoluble yellow-orange pigment derived from heme catabolism, accumulates
to toxic levels in individuals with impaired or immature liver function. The resulting jaundice …

Structure, properties, and engineering of the major zinc binding site on human albumin

CA Blindauer, I Harvey, KE Bunyan, AJ Stewart… - Journal of Biological …, 2009 - ASBMB
Most blood plasma zinc is bound to albumin, but the structure of the binding site has not
been determined. Zn K-edge extended x-ray absorption fine structure spectroscopy and …

The effect of glycation on the structure, function and biological fate of human serum albumin as revealed by recombinant mutants

K Nakajou, H Watanabe, U Kragh-Hansen… - … et Biophysica Acta (BBA …, 2003 - Elsevier
Recombinant wild-type human serum albumin (rHSA), the single-residue mutants K199A,
K439A and K525A and the triple-residue mutant K199A/K439A/K525A were produced using …

Immobilization of BSA on silica-coated magnetic iron oxide nanoparticle

CH Yu, A Al-Saadi, SJ Shih, L Qiu… - The Journal of …, 2009 - ACS Publications
Colloid stable magnetic iron oxide nanoparticles, which undergo reversible precipitation
from aqueous solution with external magnetic flux, can have many potential applications …

The role of the protein-binding on the mode of drug action as well the interactions with other drugs

C Tesseromatis, A Alevizou - European journal of drug metabolism and …, 2008 - Springer
Drug transport and disposition are influenced by a non-specific and reversible drug binding
to plasma and tissues proteins. Albumin and al acid glycoprotein are the most important …

Binding of chloroquine–conjugated gold nanoparticles with bovine serum albumin

P Joshi, S Chakraborty, S Dey, V Shanker… - Journal of colloid and …, 2011 - Elsevier
We have conjugated chloroquine, an anti-malarial, antiviral and anti-tumor drug, with thiol-
functionalized gold nanoparticles and studied their binding interaction with bovine serum …

Serum heme‐albumin: an allosteric protein

P Ascenzi, M Fasano - IUBMB life, 2009 - Wiley Online Library
Heme scavenging by plasma proteins, including serum albumin (SA), provides protection
against free‐heme oxidative damage, limits access by pathogens to the heme, and …