Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

X Zhu, Z Chen, W Shen, G Huang, JM Sedivy… - Signal transduction and …, 2021 - nature.com
Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Mitochondrial dysfunction in aging

Y Guo, T Guan, K Shafiq, Q Yu, X Jiao, D Na… - Ageing Research …, 2023 - Elsevier
Aging is a complex process that features a functional decline in many organelles. Although
mitochondrial dysfunction is suggested as one of the determining factors of aging, the role of …

Foliar application of zinc oxide nanoparticles: An effective strategy to mitigate drought stress in cucumber seedling by modulating antioxidant defense system and …

MI Ghani, S Saleem, SA Rather, MS Rehmani, S Alamri… - Chemosphere, 2022 - Elsevier
Drought is a major environmental threat that affects plant growth and productivity. Strategies
to mitigate the detrimental impacts of drought stress on plants are under scrutiny …

Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells

X Qin, J Zhang, B Wang, G Xu, X Yang, Z Zou, C Yu - Autophagy, 2021 - Taylor & Francis
Zinc oxide nanoparticles (ZnONPs) hold great promise for biomedical applications. Previous
studies have revealed that ZnONPs exposure can induce toxicity in endothelial cells, but the …

PGC‐1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism

S Rius-Pérez, I Torres-Cuevas, I Millán… - Oxidative medicine …, 2020 - Wiley Online Library
Peroxisome proliferator‐activated receptor‐γ coactivator (PGC)‐1α is a transcriptional
coactivator described as a master regulator of mitochondrial biogenesis and function …

The interplay of ROS and the PI3K/Akt pathway in autophagy regulation

L Kma, TJ Baruah - Biotechnology and applied biochemistry, 2022 - Wiley Online Library
Autophagy causes the breakdown of damaged proteins and organelles to their constituent
components. The phosphatidylinositol 3‐kinase (PI3K) pathway played an important role in …

Unraveling the complex interplay between T cell metabolism and function

RI Klein Geltink, RL Kyle… - Annual review of …, 2018 - annualreviews.org
Metabolism drives function, on both an organismal and a cellular level. In T cell biology,
metabolic remodeling is intrinsically linked to cellular development, activation, function …

Mitochondrial redox signaling and oxidative stress in kidney diseases

AK Aranda-Rivera, A Cruz-Gregorio, OE Aparicio-Trejo… - Biomolecules, 2021 - mdpi.com
Mitochondria are essential organelles in physiology and kidney diseases, because they
produce cellular energy required to perform their function. During mitochondrial metabolism …

Reactive oxygen species and mitochondrial dynamics: the yin and yang of mitochondrial dysfunction and cancer progression

J Ježek, KF Cooper, R Strich - Antioxidants, 2018 - mdpi.com
Mitochondria are organelles with a highly dynamic ultrastructure maintained by a delicate
equilibrium between its fission and fusion rates. Understanding the factors influencing this …

Signaling pathways related to oxidative stress in diabetic cardiomyopathy

M Peng, Y Fu, C Wu, Y Zhang, H Ren… - Frontiers in …, 2022 - frontiersin.org
Diabetes is a chronic metabolic disease that is increasing in prevalence and causes many
complications. Diabetic cardiomyopathy (DCM) is a complication of diabetes that is …