Macromolecules, dendrimers, and nanomaterials in magnetic resonance imaging: the interplay between size, function, and pharmacokinetics

AJL Villaraza, A Bumb, MW Brechbiel - Chemical reviews, 2010 - ACS Publications
Magnetism in medicine has had a long and interesting history. In the 10th century AD,
Egyptian physician and philosopher Avicenna prescribed a grain of magnetite dissolved in …

Prodrug strategies in anticancer chemotherapy

F Kratz, IA Müller, C Ryppa… - … Chemistry Enabling Drug …, 2008 - Wiley Online Library
The majority of clinically approved anticancer drugs are characterized by a narrow
therapeutic window that results mainly from a high systemic toxicity of the drugs in …

Efficient liver targeting by polyvalent display of a compact ligand for the asialoglycoprotein receptor

CA Sanhueza, MM Baksh, B Thuma… - Journal of the …, 2017 - ACS Publications
A compact and stable bicyclic bridged ketal was developed as a ligand for the
asialoglycoprotein receptor (ASGPR). This compound showed excellent ligand efficiency …

Lanthanide-based tools for the investigation of cellular environments

E Mathieu, A Sipos, E Demeyere, D Phipps… - Chemical …, 2018 - pubs.rsc.org
Biological probes constructed from lanthanides can provide a variety of readout signals,
such as the luminescence of Eu (III), Tb (III), Yb (III), Sm (III) and Dy (III), and the proton …

Noninvasive imaging of dendrimer‐type N‐glycan clusters: In vivo dynamics dependence on oligosaccharide structure

K Tanaka, ERO Siwu, K Minami… - Angewandte …, 2010 - Wiley Online Library
Among the various types of oligosaccharide structures, asparagine-linked oligosaccharides
(N-glycans) are the most prominent in terms of diversity and complexity. In particular, N …

MRI contrast agents in glycobiology

CFGC Geraldes, JA Peters - Molecules, 2022 - mdpi.com
Molecular recognition involving glycoprotein-mediated interactions is ubiquitous in both
normal and pathological natural processes. Therefore, visualization of these interactions …

Superparamagnetic iron oxide nanoparticles as a dual imaging probe for targeting hepatocytes in vivo

CM Lee, HJ Jeong, EM Kim, DW Kim… - … in Medicine: An …, 2009 - Wiley Online Library
Hepatocyte‐specific targeting agents are useful for evaluation of the hepatocytic function
and the monitoring of disease progress. Superparamagnetic iron oxide nanoparticles …

Prospects of metal complexes peripherally substituted with sugars in biomedicinal applications

M Gottschaldt, US Schubert - Chemistry–A European Journal, 2009 - Wiley Online Library
Sugar is good for you! The latest developments in the field of sugar substitution of metal
complexes and its influence on the action of these complexes in biological systems are …

Research progress on asialoglycoprotein receptor-targeted radiotracers designed for hepatic nuclear medicine imaging

Y Hua, C Yu - European Journal of Medicinal Chemistry, 2024 - Elsevier
Asialoglycoprotein receptor (ASGPR) specifically recognizes glycans terminated with β-d-
galactose or N-acetylgalactosamine. Its exclusive expression in mammalian hepatocytes …

Multifunctional gadolinium-based dendritic macromolecules as liver targeting imaging probes

K Luo, G Liu, B He, Y Wu, Q Gong, B Song, H Ai, Z Gu - Biomaterials, 2011 - Elsevier
The quest for highly efficient and safe contrast agents has become the key factor for
successful application of magnetic resonance imaging (MRI). The gadolinium (Gd) based …