A wide variety of soluble signaling substances utilize the cyclic AMP-dependent protein
kinase (PKA) pathway to regulate cellular behaviors including intermediary metabolism, ion …

Steroid hormone biosynthesis in the adrenal cortex and gonads involves the coordinated
transcription of the genes encoding the steroid hydroxylases, 3β‐hydroxysteroid …

Although the contribution of mitochondrial dynamics (a balance in fusion/fission events and
changes in mitochondria subcellular distribution) to key biological process has been …

The pituitary adrenocorticotropic hormone (ACTH) plays a pivotal role in homeostasis and
stress response and is thus the major component of the hypothalamo–pituitary–adrenal axis …

Cloning of the individual regulatory (R) and catalytic (C) subunits of the cAMP‐dependent
protein kinase (PKA) and expression of these subunits in cell culture have provided …

ACTH does not affect delivery of cholesterol to mitochondria but results in accumulation of
cholesterol in OMM and a corresponding loss of IMM cholesterol. Cholesterol-P450scc …

Here, we demonstrate that elevation of intracellular cyclic AMP (cAMP) in vascular
endothelial cells (ECs) by either a direct activator of adenylyl cyclase or endogenous cAMP …

The cholinergic anti-inflammatory pathway is a physiological mechanism that inhibits
cytokine production and minimizes tissue injury during inflammation. Previous investigations …

ACTH is the major regulator of adrenal cortex function, having acute and chronic effects on
steroid synthesis and secretion. The precise molecular mechanisms by which ACTH …

Vascular endothelial–cadherin (VE-cadherin) plays a key role in angiogenesis and in
vascular permeability. The regulation of its biological activity may be a central mechanism in …