Mean-field (MF) models are computational formalism used to summarize in a few statistical
parameters the salient biophysical properties of an inter-wired neuronal network. Their …

The cerebellum plays a crucial role in motor learning and memory, and recent studies have
proposed various cerebellar models to investigate these functions. This review examines the …

Ataxia-telangiectasia-like disorder 1 (ATLD1) is a rare neurodegenerative disorder
associated with early onset ataxia and oculomotor apraxia. The genetic determination of …

Brain lesions exclusive to dystonia, or specific forms of it, such as isolated dystonia, have
been rarely described. While the identification of distinctive intra-or extraneuronal …

Parkinsonism is presented as a motor syndrome characterized by rigidity, tremors, and
bradykinesia, with Parkinson's disease (PD) being the predominant cause. The discovery …

Parkinson's disease (PD) is a chronic degenerative disorder of the central nervous system
that affects the motor system. The discovery that PD motor symptoms result from the death of …

According to the motor learning theory by Albus and Ito, synaptic depression at the parallel
fibre to Purkinje cells synapse (pf-PC) is the main substrate responsible for learning …

Background and purpose Postmortem brain study indicated that cerebellar Purkinje cell
(PC) loss might be a pathological finding in patients with inherited and idiopathic cervical …

Nitric Oxide (NO) is a versatile signalling molecule with significant roles in various
physiological processes, including synaptic plasticity and memory formation. In the …

Background Cervical dystonia is a movement disorder, characterised by involuntary head
and neck muscle contractions. Although deep brain stimulation (DBS) of the globus pallidus …