Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD,
Myogenin and MRF4 was a seminal step in understanding specification of the skeletal …

Chargé, Sophie BP, and Michael A. Rudnicki. Cellular and Molecular Regulation of Muscle
Regeneration. Physiol Rev 84: 209–238, 2004; 10.1152/physrev. 00019.2003.—Under …

Adult skeletal muscle has a remarkable ability to regenerate following myotrauma. Because
adult myofibers are terminally differentiated, the regeneration of skeletal muscle is largely …

I. Overview T HE general characterization of the growth hormone/insulin-like growth factor-I
(GH/IGF-I) system has been established for a considerable length of time, and we will not …

Each skeletal muscle acquires its unique size before birth, when terminally differentiating
myocytes fuse to form a defined number of multinucleated myofibres. Although mice in which …

Introduction 3. Development and determination of the myogenic lineage 3.1. Somitogenesis:
formation of epaxial versus hypaxial musculature 3.2. The myogenic regulatory factors 3.2 …

Myoblast fusion is essential for formations of myofibers, the basic cellular and functional
units of skeletal muscles. Recent genetic studies in mice identified two long-sought …

Since the seminal discovery of the cell-fate regulator Myod, studies in skeletal myogenesis
have inspired the search for cell-fate regulators of similar potential in other tissues and …

The expression of three microRNAs, miR-1, miR-206 and miR-133 is restricted to skeletal
myoblasts and cardiac tissue during embryo development and muscle cell differentiation …

The muscle‐specific basic helix–loop–helix proteins M yo D, M yf5, myogenin (M yog) and
MRF 4 constitute the myogenic regulatory factor (MRF) family of transcription factors that …