X-chromosome inactivation (XCI) is a developmentally associated process that evolved in
mammals to enable gene dosage compensation between XX and XY individuals. In …

Early in development, placental and marsupial mammals harbouring at least two X
chromosomes per nucleus are faced with a choice that affects the rest of their lives: which of …

Genotyping microarrays are an important resource for genetic mapping, population genetics,
and monitoring of the genetic integrity of laboratory stocks. We have developed the third …

Complex human traits are influenced by variation in regulatory DNA through mechanisms
that are not fully understood. Because regulatory elements are conserved between humans …

To determine the dynamics of allelic-specific expression during mouse development, we
analyzed RNA-seq data from 23 F1 tissues from different developmental stages, including …

Genomic imprinting and X chromosome inactivation (XCI) require epigenetic mechanisms to
encode allele-specific expression, but how these specific tasks are accomplished at single …

X-chromosome inactivation and X-upregulation are the fundamental modes of chromosome-
wide gene regulation that collectively achieve dosage compensation in mammals, but the …

Here, we report a single-cell DNA replication sequencing method, scRepli-seq, a genome-
wide methodology that measures copy number differences between replicated and …

X chromosome inactivation (XCI) is the process of silencing one of the X chromosomes in
cells of the female mammal which ensures dosage compensation between the sexes …

Here, we describe an RNA-sequencing (RNA-seq)-based approach that accurately detects
even modest maternal or paternal allele expression biases at the tissue level, which we call …