Linoleic acid (LA) is the most abundant polyunsaturated fatty acid found in the Western diet.
Cytochrome P450-derived LA metabolites 9, 10-epoxyoctadecenoic acid (9, 10-EpOME), 12 …

Paclitaxel is a chemotherapeutic agent widely used for many types of malignancies.
However, when paclitaxel is used to treat tumors, patients commonly experience severe …

The innate immune regulator STING is a critical sensor of self-and pathogen-derived DNA.
DNA sensing by STING leads to the induction of type-I interferons (IFN-I) and other …

Increased tetrahydrobiopterin (BH4) generated in injured sensory neurons contributes to
increased pain sensitivity and its persistence. GTP cyclohydrolase 1 (GCH1) is the rate …

Abnormal Ca2+ channel physiology, expression levels, and hypersensitivity to heat have
been implicated in several pain states following treatment with chemotherapeutic agents. As …

Chronic pain is the leading cause of disability worldwide and is commonly associated with
comorbid disorders. However, the role of diet in chronic pain is poorly understood. Of …

Chemotherapy, nerve injuries, or diseases like multiple sclerosis can cause
pathophysiological processes of persistent and neuropathic pain. Thereby, the activation …

Purpose To explore the potential therapeutic strategies of different types of neuropathic pain
(NP) and to summarize the cutting-edge novel approaches for NP treatment based on the …

Chemotherapy-induced peripheral neuropathy (CIPN) is a severe adverse effect observed
in most patients treated with neurotoxic anti-cancer drugs. Currently, there are no …

Eicosanoids play a crucial role in inflammatory pain. However, there is very little knowledge
about the contribution of oxidized linoleic acid metabolites in inflammatory pain and …