Cushing's disease requires accurate diagnosis, careful treatment selection, and long-term
management to optimise patient outcomes. The Pituitary Society convened a consensus …

Importance Pituitary adenomas are neoplasms of the pituitary adenohypophyseal cell
lineage and include functioning tumors, characterized by the secretion of pituitary hormones …

Background Aldosterone synthase controls the synthesis of aldosterone and has been a
pharmacologic target for the treatment of hypertension for several decades. Selective …

Cushing's disease (CD) is a serious endocrine disorder characterized by chronic
hypercortisolism, or Cushing's syndrome (CS), caused by a corticotroph pituitary tumor …

Importance Cushing syndrome is defined as a prolonged increase in plasma cortisol levels
that is not due to a physiological etiology. Although the most frequent cause of Cushing …

Prolonged excess of glucocorticoids (GCs) has adverse systemic effects leading to
significant morbidities and an increase in mortality. Metabolic alterations associated with the …

Objective To investigate the long-term efficacy and tolerability of osilodrostat, a potent oral
11β-hydroxylase inhibitor, for treating Cushing's disease (CD). Design/methods A total of …

Abstract Purpose: Literature regarding endogenous Cushing syndrome (CS) largely focuses
on the challenges of diagnosis, subtyping, and treatment. The enigmatic phenomenon of …

Steroidogenesis inhibitors can be given to control the hypercortisolism of Cushing's
syndrome in various situations: when surgery has been unsuccessful or not possible; in …

Context Cushing disease, a chronic hypercortisolism disorder, is associated with
considerable morbidity and mortality. Normalizing cortisol production is the primary …