Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH

M Dudek, D Pfister, S Donakonda, P Filpe, A Schneider… - Nature, 2021 - nature.com
Nonalcoholic steatohepatitis (NASH) is a manifestation of systemic metabolic disease
related to obesity, and causes liver disease and cancer,. The accumulation of metabolites …

The UCSC genome browser database: 2021 update

J Navarro Gonzalez, AS Zweig, ML Speir… - Nucleic acids …, 2021 - academic.oup.com
For more than two decades, the UCSC Genome Browser database (https://genome. ucsc.
edu) has provided high-quality genomics data visualization and genome annotations to the …

The UCSC genome browser database: 2019 update

M Haeussler, AS Zweig, C Tyner, ML Speir… - Nucleic acids …, 2019 - academic.oup.com
Abstract The UCSC Genome Browser (https://genome. ucsc. edu) is a graphical viewer for
exploring genome annotations. For almost two decades, the Browser has provided …

Reductive carboxylation epigenetically instructs T cell differentiation

A Jaccard, T Wyss, N Maldonado-Pérez, JA Rath… - Nature, 2023 - nature.com
Protective immunity against pathogens or cancer is mediated by the activation and clonal
expansion of antigen-specific naive T cells into effector T cells. To sustain their rapid …

Sequence determinants of human gene regulatory elements

B Sahu, T Hartonen, P Pihlajamaa, B Wei, K Dave… - Nature Genetics, 2022 - nature.com
DNA can determine where and when genes are expressed, but the full set of sequence
determinants that control gene expression is unknown. Here, we measured the …

Roles and regulation of BCL-xL in hematological malignancies

M Morales-Martínez, MI Vega - International journal of molecular sciences, 2022 - mdpi.com
Members of the Bcl-2 family are proteins that play an essential role in the regulation of
apoptosis, a crucial process in development and normal physiology in multicellular …

Clocks, viruses, and immunity: lessons for the COVID-19 pandemic

S Sengupta, L Ince, F Sartor… - Journal of biological …, 2021 - journals.sagepub.com
Circadian rhythms are evolutionarily conserved anticipatory systems that allow the host to
prepare and respond to threats in its environment. This article summarizes a European …

Genomic analysis of vascular invasion in HCC reveals molecular drivers and predictive biomarkers

MS Krishnan, A Rajan KD, J Park, V Arjunan… - …, 2021 - Wiley Online Library
Background and Aims Vascular invasion (VI) is a critical risk factor for HCC recurrence and
poor survival. The molecular drivers of vascular invasion in HCC are open for investigation …

ChIP-DIP maps binding of hundreds of proteins to DNA simultaneously and identifies diverse gene regulatory elements

AA Perez, IN Goronzy, MR Blanco, BT Yeh, JK Guo… - Nature Genetics, 2024 - nature.com
Gene expression is controlled by dynamic localization of thousands of regulatory proteins to
precise genomic regions. Understanding this cell type-specific process has been a …

Connexins orchestrate progression of breast cancer metastasis to the brain by promoting FAK activation

G Lorusso, CB Wyss, F Kuonen, N Vannini… - Science translational …, 2022 - science.org
Brain metastasis is a complication of increasing incidence in patients with breast cancer at
advanced disease stage. It is a severe condition characterized by a rapid decline in quality …