Background Long courses of oral corticosteroids are commonly used in children in the
management of chronic conditions. Various adverse drug reactions (ADRs) are known to …

Glucocorticoid therapy is widely used, but withdrawal from glucocorticoids comes with a
potential life-threatening risk of adrenal insufficiency. Recent case reports document that …

Liposomes have been extensively investigated as drug delivery systems in the treatment of
rheumatoid arthritis (RA). Low bioavailability, high clearance rates and limited selectivity of …

Background Glucocorticoids play a major role in the treatment of acute lymphoblastic
leukaemia (ALL). However, supraphysiological doses can suppress the hypothalamic …

Secondary adrenal insufficiency can result from insufficient stimulation of the adrenal glands
due to inadequate secretion or synthesis of adrenocorticotropic hormone (ACTH). This can …

Glucocorticoids are, besides non-steroidal anti-inflammatory drugs, the most widely used
anti-inflammatory medications. Prevalence studies indicate substantial use of both systemic …

The past 30 years have seen a great improvement in survival of children and young adults
treated for cancer. Cancer treatment can put patients at risk of health problems that can …

Background A 4‐week course of high‐dose glucocorticoids may cause prolonged adrenal
suppression even after a 9‐day tapering phase. In this study, adrenal function and signs and …

Context: Recovery of the hypothalamic-pituitary-adrenal axis (HPAA) after transsphenoidal
surgery (TSS) for Cushing's disease (CD) in children has not been adequately studied …

Hyperacusis, a debilitating loudness intolerance disorder, has been linked to chronic stress
and adrenal insufficiency. To investigate the role of chronic stress, rats were chronically …