Recent advances in microfluidic technology have made it possible to image live bacterial
cells with a high degree of precision and control. In particular, single-cell microfluidic …

Phenotypic variations between individual microbial cells play a key role in the resistance of
microbial pathogens to pharmacotherapies. Nevertheless, little is known about cell …

The interactions between bacteria and bacteriophage have important roles in the global
ecosystem; in turn changes in environmental parameters affect the interactions between …

Throughout human history, inexhaustible emerging or re-emerging pathogenic bacteria
have never ceased to pose significant challenges to global public health. As the other side …

The double-membrane cell envelope of Gram-negative bacteria is a formidable barrier to
intracellular antibiotic accumulation. A quantitative understanding of antibiotic transport in …

With the spread of multidrug-resistant bacteria, there has been an increasing focus on
molecular classes that have not yet yielded an antibiotic. A key capability for assessing and …

A key mechanism driving antimicrobial resistance (AMR) stems from the ability of bacteria to
up-regulate efflux pumps upon exposure to drugs. The resistance gained by this up …

The interactions between a virus and its host vary in space and time and are affected by the
presence of molecules that alter the physiology of either the host or the virus. Determining …

Acinetobacter baumannii causes high mortality in ventilator-associated pneumonia patients,
and antibiotic treatment is compromised by multidrug-resistant strains resistant to β-lactams …

Many antibiotics that are used in healthcare, farming, and aquaculture end up in
environments with different spatial structures that might promote heterogeneity in the …