Fifty years have elapsed since the term common variable immunodeficiency (CVID) was
introduced to accommodate the many and varied antibody deficiencies being identified in …

Common variable immunodeficiency (CVID) is the most common symptomatic primary
immunodeficiency (PID). CVID is a heterogenous condition and clinical manifestations may …

Patients with inborn errors of immunity (IEI) are susceptible to developing a severe infection-
related clinical phenotype, but the clinical consequences of immune dysregulation …

Monogenic immune dysregulation diseases (MIDD) are caused by defective
immunotolerance. This study was designed to increase knowledge on the prevalence and …

Background LPS-responsive beige-like anchor (LRBA) deficiency (LRBA–/–) and cytotoxic T-
lymphocyte–associated antigen-4 (CTLA4) insufficiency (CTLA4+/–) are mechanistically …

Recent advances in cancer immunotherapy have completely revolutionized cancer
treatment strategies. Nonetheless, the increasing incidence of immune-related adverse …

Lymphadenopathies can be part of the clinical spectrum of several primary
immunodeficiencies, including diseases with immune dysregulation and autoinflammatory …

Background Lipopolysaccharide‐responsive beige‐like anchor protein (LRBA) deficiency
and cytotoxic T‐lymphocyte protein‐4 (CTLA‐4) insufficiency are recently described …

Since its first description by Evans in 1951, this syndrome has been linked to chronic
immune thrombocytopenia with the concurrent or delayed onset of autoimmune haemolytic …

Regulatory T cells (Tregs) play a crucial role in enforcing immune tolerance in the periphery,
preventing the activation of autoreactive cells, production of autoantibodies, and …