[HTML][HTML] Toward electrophysiology-based intelligent adaptive deep brain stimulation for movement disorders
Deep brain stimulation (DBS) represents one of the major clinical breakthroughs in the age
of translational neuroscience. In 1987, Benabid and colleagues demonstrated that high …
of translational neuroscience. In 1987, Benabid and colleagues demonstrated that high …
Targeting neural circuits
Optogenetic methodology enables direct targeting of specific neural circuit elements for
inhibition or excitation while spanning timescales from the acute (milliseconds) to the …
inhibition or excitation while spanning timescales from the acute (milliseconds) to the …
Neuromodulation targets pathological not physiological beta bursts during gait in Parkinson's disease
Freezing of gait (FOG) is a devastating axial motor symptom in Parkinson's disease (PD)
leading to falls, institutionalization, and even death. The response of FOG to dopaminergic …
leading to falls, institutionalization, and even death. The response of FOG to dopaminergic …
Phase-dependent suppression of beta oscillations in Parkinson's disease patients
AB Holt, E Kormann, A Gulberti… - Journal of …, 2019 - Soc Neuroscience
Synchronized oscillations within and between brain areas facilitate normal processing, but
are often amplified in disease. A prominent example is the abnormally sustained beta …
are often amplified in disease. A prominent example is the abnormally sustained beta …
Frequency-dependent effects of subthalamic deep brain stimulation on motor symptoms in Parkinson's disease: a meta-analysis of controlled trials
D Su, H Chen, W Hu, Y Liu, Z Wang, X Wang, G Liu… - Scientific reports, 2018 - nature.com
This study aims to investigate how the frequency settings of deep brain stimulation (DBS)
targeting the subthalamic nucleus (STN) influence the motor symptoms of Parkinson's …
targeting the subthalamic nucleus (STN) influence the motor symptoms of Parkinson's …
[HTML][HTML] La enfermedad de Parkinson: Etiología, tratamientos y factores preventivos
F Hurtado, MA N Cárdenas, F Cardenas… - Universitas …, 2016 - scielo.org.co
La enfermedad de Parkinson (EP) es la patología neurodegenerativa motora con mayor
incidencia a nivel mundial, cuyas causas aún no son claras. Actualmente no existe cura …
incidencia a nivel mundial, cuyas causas aún no son claras. Actualmente no existe cura …
Future therapeutic strategies for freezing of gait in Parkinson's disease
CK Cui, SJG Lewis - Frontiers in Human Neuroscience, 2021 - frontiersin.org
Freezing of gait (FOG) is a common and challenging clinical symptom in Parkinson's
disease. In this review, we summarise the recent insights into freezing of gait and highlight …
disease. In this review, we summarise the recent insights into freezing of gait and highlight …
Sixty‐hertz stimulation improves bradykinesia and amplifies subthalamic low‐frequency oscillations
Z Blumenfeld, MM Koop, TE Prieto… - Movement …, 2017 - Wiley Online Library
Background The objective of this study was to investigate the hypothesis that attenuation of
subthalamic nucleus (STN) alpha‐/beta‐band oscillations is causal to improvement in …
subthalamic nucleus (STN) alpha‐/beta‐band oscillations is causal to improvement in …
Cortical network effects of subthalamic deep brain stimulation in a thalamo-cortical microcircuit model
AA Farokhniaee, MM Lowery - Journal of Neural Engineering, 2021 - iopscience.iop.org
Objective. High frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN)
suppresses excessive beta band (∼ 13–30 Hz) activity of the motor cortex in Parkinson's …
suppresses excessive beta band (∼ 13–30 Hz) activity of the motor cortex in Parkinson's …
Low-frequency subthalamic stimulation in Parkinson's disease: long-term outcome and predictors
Background Parkinson's disease patients undergoing subthalamic nucleus deep brain
stimulation (STN DBS) at standard frequency (> 100 Hz) often develop gait impairment …
stimulation (STN DBS) at standard frequency (> 100 Hz) often develop gait impairment …