Progranulin (PGRN), encoded by the GRN gene in humans, was originally isolated as a
secreted growth factor that implicates in a multitude of processes ranging from regulation of …

The neuronal ceroid lipofuscinoses (NCLs), also referred to as Batten disease, are a family
of neurodegenerative diseases that affect all age groups and ethnicities around the globe. At …

Background Progranulin (PGRN) is a lysosomal glycoprotein implicated in various
neurodegenerative diseases, including frontotemporal dementia and neuronal ceroid …

Autophagy is a lysosomal-dependent degradation process of eukaryotic cells responsible
for breaking down unnecessary and damaged intracellular components. Autophagic activity …

Mutations in GBA1, encoding glucocerebrosidase (GCase), cause Gaucher disease (GD)
and are also genetic risks in developing Parkinson's disease (PD). Currently, the approved …

Progranulin (PGRN), which is produced in neurons and microglia, is a neurotrophic and anti-
inflammatory glycoprotein. Human loss-of-function mutations cause frontotemporal …

Gaucher disease (GD) is caused by biallelic GBA1/Gba1 mutations that encode defective
glucocerebrosidase (GCase). Progranulin (PGRN, encoded by GRN/Grn) is a modifier of …

Fungal keratitis (FK) is a severe corneal condition caused by pathogenic fungi and is
associated with the virulence of fungi and an excessive tissue inflammatory response …

Gaucher disease (GD), one of the most common lysosomal storage diseases, is caused by
GBA1 mutations resulting in defective glucocerebrosidase (GCase) and consequent …

Introduction Gaucher disease is a lysosomal storage disease due to deficiency of
glucocerebrosidase, leading to the accumulation of glucosylceramide, particularly in …