Colorectal cancer (CRC) is the third most common cancer and the fourth most common
cause of cancer-related death. Most cases of CRC are detected in Western countries, with its …

Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence
suggests that RNA is not only functional as a messenger between DNA and protein but also …

We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic
ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low …

Unraveling the gene expression networks governing cancer initiation and development is
essential while remains largely uncompleted. With the innovations in RNA-seq technologies …

Background To overcome the hostile hypoxic microenvironment of solid tumors, tumor cells
secrete a large number of non-coding RNA-containing exosomes that facilitate tumor …

Recent preliminary studies reported the in vitro tumor-promoting effects of long non-coding
RNA urothelial carcinoma associated 1 (UCA1) in colorectal cancer (CRC). However, the in …

Context Genomic regions without protein-coding potential give rise to millions of protein-
noncoding RNA transcripts (noncoding RNA) that participate in virtually all cellular …

Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm
demonstrating potential roles in both oncogenic and tumor suppressive pathways. These …

In addition to mutations or aberrant expression in the protein-coding genes, mutations and
misregulation of noncoding RNAs, in particular long noncoding RNAs (lncRNA), appear to …

Tiling array and novel sequencing technologies have made available the transcription
profile of the entire human genome. However, the extent of transcription and the function of …