Dry eye disease is a multifactorial disorder of the tears and ocular surface characterized by
symptoms of dryness and irritation. Although the pathogenesis of dry eye disease is not fully …

Dry eye is a common ocular surface inflammatory disease that significantly affects quality of
life. Dysfunction of the lacrimal function unit (LFU) alters tear composition and breaks ocular …

There is mounting evidence that the microbiome has potent immunoregulatory functions. We
assessed the effects of intestinal dysbiosis in a model of Sjögren syndrome (SS) by …

The tear film, lacrimal glands, corneal and conjunctival epithelia and Meibomian glands
work together as a lacrimal functional unit (LFU) to preserve the integrity and function of the …

Dry eye disease (DED), an inflammatory autoimmune disorder affecting the ocular surface,
degrades visual performance and the quality of life of> 10 million people in the United States …

This article reviews the literature and summarizes the role of inflammation in dry eye
disease. A PubMed search was performed using the keywords inflammatory cycle and dry …

Abstract The classic Th1/Th2 dogma has been significantly reshaped since the subsequent
introduction of several new T helper cell subsets, among which the most intensively …

A healthy ocular surface environment is essential to preserve visual function, and as such
the eye has evolved a complex network of mechanisms to maintain homeostasis …

As specialized sentinels between the innate and adaptive immune response, APCs are
essential for activation of Ag-specific lymphocytes, pathogen clearance, and generation of …

Integrins belong to a group of cell adhesion molecules (CAMs) which is a large group of
membrane-bound proteins. They are responsible for cell attachment to the extracellular …