Highlights•Technologic advances confront society with the inadequacies of extant
norms.•Scientific characterization of the continuum of life lacks natural boundaries.•Scientific …

The progress in neuroimaging and electrophysiological techniques has shown substantial
promise in improving the clinical assessment of disorders of consciousness (DOC). Through …

Spectrum power analysis in the low frequency oscillations (LFO) region of functional near
infrared spectroscopy (fNIRS) is a promising method to deliver information about brain …

A fundamental challenge in neuroscience is accurately defining brain states and predicting
how and where to perturb the brain to force a transition. Here, we investigated resting-state …

Consciousness is a mental property, specifically the ability to experience feelings that yield a
subjective point of view (see “Definitions” in Box 1). The mechanisms of consciousness …

Aberrant alterations in any of the two dimensions of consciousness, namely awareness and
arousal, can lead to the emergence of disorders of consciousness (DOC). The development …

Modern medicine has been shaken by the surge of psychedelic science that proposes a
new approach to mitigate mental disorders, such as depression and post-traumatic stress …

Prognostication in patients with disorders of consciousness is a complex clinical problem,
which can be impacted by multiple factors. The current approach to the assessment of …

The Curing Coma Campaign (CCC) and its contributing collaborators identified multiple key
areas of knowledge and research gaps in coma and disorders of consciousness (DoC). This …

A fundamental challenge in neuroscience is accurately defining brain states and predicting
how and where to perturb the brain to force a transition. The ability to promote a transition …