Impact of Mediterranean diet on chronic non-communicable diseases and longevity

LJ Dominguez, G Di Bella, N Veronese, M Barbagallo - Nutrients, 2021 - mdpi.com
The average life expectancy of the world population has increased remarkably in the past
150 years and it is still increasing. A long life is a dream of humans since the beginning of …

The anti-inflammatory properties of phytochemicals and their effects on epigenetic mechanisms involved in TLR4/NF-κB-mediated inflammation

HA Saleh, MH Yousef, A Abdelnaser - Frontiers in immunology, 2021 - frontiersin.org
Innate immune response induces positive inflammatory transducers and regulators in order
to attack pathogens, while simultaneously negative signaling regulators are transcribed to …

[HTML][HTML] Brain changes in a maternal immune activation model of neurodevelopmental brain disorders

L Bergdolt, A Dunaevsky - Progress in neurobiology, 2019 - Elsevier
The developing brain is sensitive to a variety of insults. Epidemiological studies have
identified prenatal exposure to infection as a risk factor for a range of neurological disorders …

Sulforaphane: its “coming of age” as a clinically relevant nutraceutical in the prevention and treatment of chronic disease

CA Houghton - Oxidative medicine and cellular longevity, 2019 - Wiley Online Library
A growing awareness of the mechanisms by which phytochemicals can influence upstream
endogenous cellular defence processes has led to intensified research into their potential …

Mediterranean-type dietary pattern and physical activity: The winning combination to counteract the rising burden of non-communicable diseases (NCDS)

G Caprara - Nutrients, 2021 - mdpi.com
Non-communicable diseases (NCDs)(mainly cardiovascular diseases, cancers, chronic
respiratory diseases and type 2 diabetes) are the main causes of death worldwide. Their …

[HTML][HTML] Therapeutic potential of natural compounds acting through epigenetic mechanisms in cardiovascular diseases: Current findings and future directions

P Bontempo, L Capasso, L De Masi, A Nebbioso… - Nutrients, 2024 - mdpi.com
Cardiovascular diseases (CVDs) remain a leading global cause of morbidity and mortality.
These diseases have a multifaceted nature being influenced by a multitude of biochemical …

Anticancer activity of sulforaphane: the epigenetic mechanisms and the Nrf2 signaling pathway

X Su, X Jiang, L Meng, X Dong… - Oxidative medicine and …, 2018 - Wiley Online Library
Sulforaphane (SFN), a compound derived from cruciferous vegetables that has been shown
to be safe and nontoxic, with minimal/no side effects, has been extensively studied due to its …

Sulforaphane in broccoli: The green chemoprevention!! Role in cancer prevention and therapy

DB Nandini, RS Rao, BS Deepak… - Journal of oral and …, 2020 - journals.lww.com
Isothicyanates present in cruciferous vegetables are known to exhibit chemoprevention by
various mechanisms. Presently, there is growing evidence that a phytochemical compound …

Mechanisms underlying biological effects of cruciferous glucosinolate-derived isothiocyanates/indoles: a focus on metabolic syndrome

M Esteve - Frontiers in Nutrition, 2020 - frontiersin.org
An inverse correlation between vegetable consumption and the incidence of cancer has
long been described. This protective effect is stronger when cruciferous vegetables are …

Epigenetics, microRNA and metabolic syndrome: a comprehensive review

F Ramzan, MH Vickers, RF Mithen - International Journal of Molecular …, 2021 - mdpi.com
Epigenetics refers to the DNA chemistry changes that result in the modification of gene
transcription and translation independently of the underlying DNA coding sequence …