Organoids are engineered three-dimensional tissue cultures derived from stem cells and
capable of self-renewal and self-organization into a variety of progenitors and differentiated …

Human-relevant three-dimensional (3D) models of cerebral tissue can be invaluable tools to
boost our understanding of the cellular mechanisms underlying brain pathophysiology …

Human midbrain-specific organoids (hMOs) serve as an experimental in vitro model for
studying the pathogenesis of Parkinson's disease (PD). In hMOs, neuroepithelial stem cells …

Polydimethylsiloxane (PDMS) polymers are extensively used in a wide range of research
and industrial fields, due to their highly versatile chemical, physical, and biological …

Oxygen is not only crucial for cell survival but also a determinant for cell fate and function.
However, the supply of oxygen and other nutrients as well as the removal of toxic waste …

The structural and physiological complexity of currently available liver organoids is limited,
thereby reducing their relevance for drug studies, disease modelling, and regenerative …

One of the strategies for heart regeneration includes cell delivery to the defected heart.
However, most of the injected cells do not form quick cell–cell or cell–matrix interactions …

In conventional assisted reproductive technologies (ARTs), oocytes are in vitro cultured in
static conditions. Instead, dynamic systems could better mimic the physiological in vivo …

The quest for physiologically active human hepatocyte-like cells for in vitro research and
drug screening is high. The recent progress in the field of pluripotent stem cell (PSC) …

The extracellular matrix (ECM) regulates cellular function through the dynamic
biomechanical and biochemical interplay between the resident cells and their …