Chemical synthesis is a well established route for producing many chemicals on a large
scale, but some drawbacks still exist in this process, such as unstable intermediates …

As the field of synthetic biology is developing, the prospects for de novo design of
biosynthetic pathways are becoming more and more realistic. Hence, there is an increasing …

Flux balance analysis (FBA) is a widely used computational method for characterizing and
engineering intrinsic cellular metabolism. The increasing number of its successful …

Motivation: Flux balance analysis (FBA) is a well-known technique for genome-scale
modeling of metabolic flux. Typically, an FBA formulation requires the accurate specification …

The rapid progress of molecular biology tools for directed genetic modifications, accurate
quantitative experimental approaches, high-throughput measurements, together with …

The development and application of biotechnology-based strategies has had a great socio-
economical impact and is likely to play a crucial role in the foundation of more sustainable …

Natural products are still key sources of current clinical drugs and innovative therapeutic
agents. Since wild‐type microorganisms only produce natural products in very small …

Metabolic network analysis has attracted much attention in the area of systems biology. It
has a profound role in understanding the key features of organism metabolic networks and …

The technological role of lactic acid bacteria (LAB) has consistently increased in the recent
decades. This is due to its large cellular production capabilities of metabolites with …

The human gut microbiome impacts several aspects of human health and disease, including
digestion, drug metabolism and the propensity to develop various inflammatory …