Sleeping Beauty mRNA-LNP enables stable rAAV transgene expression in mouse and NHP hepatocytes and improves vector potency
PM Zakas, SC Cunningham, A Doherty, EB van Dijk… - Molecular Therapy, 2024 - cell.com
Recombinant adeno-associated virus (rAAV) vector gene delivery systems have
demonstrated great promise in clinical trials but continue to face durability and dose-related …
demonstrated great promise in clinical trials but continue to face durability and dose-related …
A DFTB study on the electronic response of encapsulated DNA nucleobases onto chiral CNTs as a sequencer
SM Monavari, N Memarian - Scientific Reports, 2024 - nature.com
Sequencing the DNA nucleobases is essential in the diagnosis and treatment of many
diseases related to human genes. In this article, the encapsulation of DNA nucleobases with …
diseases related to human genes. In this article, the encapsulation of DNA nucleobases with …
Stable transduction of the neonatal mouse liver using a hybrid rAAV/sleeping beauty transposon gene delivery system
SC Cunningham, PM Zakas, N Sasaki… - The Journal of Gene …, 2024 - Wiley Online Library
Background Conventional adeno‐associated viral (AAV) vectors, while highly effective in
quiescent cells such as hepatocytes in the adult liver, confer less durable transgene …
quiescent cells such as hepatocytes in the adult liver, confer less durable transgene …
Analysis of DNA transposition by DNA transposases in human cells
Y Bigot, M Yamada, H Mueller, V Morell, S Alves… - bioRxiv, 2023 - biorxiv.org
This manuscript discusses the recent report “Cognate restriction of transposition by
piggyBac-like proteins” in Nucleic Acids Research by Beckermann et al and related recent …
piggyBac-like proteins” in Nucleic Acids Research by Beckermann et al and related recent …