Recent insights about pyrrolidine core skeletons in pharmacology

S Poyraz, HA Döndaş, NY Döndaş… - Frontiers in …, 2023 - frontiersin.org
To overcome numerous health disorders, heterocyclic structures of synthetic or natural origin
are utilized, and notably, the emergence of various side effects of existing drugs used for …

Exploring the latest trends in chemistry, structure, coordination, and diverse applications of 1-acyl-3-substituted thioureas: a comprehensive review

SA Ullah, A Saeed, M Azeem, MB Haider, MF Erben - RSC advances, 2024 - pubs.rsc.org
Acyl thioureas represent a privileged moiety with vast potential applicability across diverse
fields, making them the subject of extensive research efforts. The inherent flexibility of …

[HTML][HTML] Local energy decomposition (through methanol), biological activity prediction, solvents interaction (DFT) and molecular docking simulation studies of Schiff …

DR Durai, S Sowrirajan, N Elangovan, SY Alomar… - Results in …, 2023 - Elsevier
The compound PYANV was characterized by infrared, UV–Visible, fluorescence, and 1 H-13
CNMR spectral analysis. The DFT calculation was done in the structure of the molecules …

Synthesis of bioactive quercetin-boronate esters as a novel biological agent: Enzyme inhibition, anti-microbial properties, computational insights and anti-cancer …

M Yildirim, A Kilic, M Cimentepe, A Necip… - Journal of Molecular …, 2025 - Elsevier
This study introduces a novel synthesis for the quercetin-boronate esters (QB1-QB4) for
some biological applications. The structure of low-cost, easily synthesized, and …

Synthesis of Imidazole‐2,3‐dihydrothiazole Compounds as VEGFR‐2 Inhibitors and Their Support with in Silico Studies

D Osmaniye, NB Bozkurt, B Kurban… - Chemistry & …, 2023 - Wiley Online Library
Abstract In this study, 12 novel 2‐((1‐(4‐(1H‐imidazol‐1‐yl) phenyl) ethylidene)
hydrazineylidene)‐3‐ethyl‐4‐(substitutephenyl)‐2, 3‐dihydrothiazole derivatives were …

Computational Discovery of Novel Imidazole Derivatives as Inhibitors of SARS-CoV-2 Main Protease: An Integrated Approach Combining Molecular Dynamics and …

BA Babalola, AE Adegboyega - COVID, 2024 - mdpi.com
One of the most pressing challenges associated with SARS treatment is the emergence of
new variants that may be transmissible, causing more severe disease or being resistant to …

Design, synthesis and bioactivity evaluation of novel 2-(pyrazol-4-yl)-1, 3, 4-oxadiazoles containing an imidazole fragment as antibacterial agents

H Liu, S Yang, T Li, S Ma, P Wang, G Wang, S Su… - Molecules, 2023 - mdpi.com
Imidazole alkaloids, a common class of five-membered aromatic heterocyclic compounds,
exist widely in plants, animals and marine organisms. Because of imidazole's extensive and …

Spectroscopic characterization, DFT, antimicrobial activity and molecular docking studies on 4, 5-bis [(E)-2-phenylethenyl]-1H, 1′ H-2, 2′-biimidazole

M Kiruthika, R Raveena, R Yogeswaran, N Elangovan… - Heliyon, 2024 - cell.com
The newly synthesized imidazole derivative namely, 4, 5-bis [(E)-2-phenylethenyl]-1H, 1′ H-
2, 2′-biimidazole (KA1), was studied for its molecular geometry, docking studies, spectral …

Recent pharmacological insights about imidazole hybrids: a comprehensive review

S Poyraz, M Yıldırım, M Ersatir - Medicinal Chemistry Research, 2024 - Springer
In this review, we evaluated the biological activities of hybrid molecules incorporating
imidazoles—a cornerstone in medicinal chemistry known for their broad pharmacological …

Imidazole‐hydrazone derivatives: Synthesis, characterization, X‐ray structures and evaluation of anticancer and carbonic anhydrase I–II inhibition properties

H Ünver, U Acar Cevik, HE Bostancı, O Kaya… - …, 2023 - Wiley Online Library
The nine new imidazole‐hydrazone derivatives of Schiff base were synthesized from the
condensation reactions of 1‐methyl‐1H‐imidazole‐2‐carbaldehyde with various substituted …